Systems Biology

1. Front Matter

   Pages i-xvii

   PDF

2. The Structure and Function of Living Organisms

   • Leszek Konieczny, Irena Roterman-Konieczna, Paweł Spólnik

   Pages 1-52Open Access

3. Energy in Biology: Demand and Use

   • Leszek Konieczny, Irena Roterman-Konieczna, Paweł Spólnik

   Pages 53-85Open Access

4. Information: Its Role and Meaning in Organisms

   • Leszek Konieczny, Irena Roterman-Konieczna, Paweł Spólnik

   Pages 87-157Open Access

5. Regulation in Biological Systems

   • Leszek Konieczny, Irena Roterman-Konieczna, Paweł Spólnik

   Pages 159-203Open Access

6. Interrelationship in Organized Biological Systems

   • Leszek Konieczny, Irena Roterman-Konieczna, Paweł Spólnik

   Pages 205-257Open Access

This open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology.

The fully updated 2nd edition also contains information that has only become available as a result of the increase in knowledge in recent years. This includes information on tumorigenesis, where significant progress has been made due to the explosive development of genetic knowledge as well as bioengineering with a highly effective technique adopted from the solutions of the bacterial world, such as CRISPR/CAS.

This richly illustrated book is essential for postgraduate students and scientists of the following disciplines: biology, biotechnology, medicine, bioinformatics, robotics and automation, biocybernetics, and biomedical engineering. It is also an exciting read for anyone interested in biology.

• Systems Biology
• Open Access
• Biological circuits
• Computational models
• Biological networks
• Biological systems
• Synthetic biology
• Bioinformatics
• Gene regulatory networks

• Chair of Biochemistry, Jagiellonian University Medical College, Krakow, Poland

  Leszek Konieczny

• Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland

  Irena Roterman-Konieczna

• KMG Kliniken SE, Wittstock, Germany

  Paweł Spólnik

Prof. emeritus Leszek Konieczny, MD, is Professor of Biochemistry at the Medical College of Jagiellonian University, Poland. His background is in medicine and his research focuses on immunochemistry and target-oriented drug transport. He is the author of numerous scientific papers in the field of protein structure, function and immunochemistry. He teaches biochemistry to medical students and has authored several textbooks on systems biology and protein structure.

Prof. Irena Roterman-Konieczna, PhD, is Professor of Medical Sciences at the Medical College of Jagiellonian University, Poland. Her background is in bioinformatics and theoretical chemistry. She was included in 2020, 2021 and 2022 on the Stanford World Ranking Top 2% Scientists. Her scientific interests focus on protein structure, function and amyloidosis. She is involved in numerous international scientific collaborations and is the Polish Chief of the EuChinaGrid network. She has authored highly successful textbooks for medical and life sciences students interested in learning about simulations in medicine, bioinformatics, statistics and systems biology.

Paweł Spólnik, MD, PhD, obtained his PhD in 2005 at the Medical College, Jagiellonian University, Poland. He studied medicine at the Faculty of Medicine of Jagiellonian University and specialised in internal medicine and cardiology. Currently, he works as an Interventional Cardiologist in Germany.