Basic and Translational Applications of the Network Theory for Dystonia

1. Front Matter

   Pages i-xi

   PDF

2. Dystonia in Childhood: How Insights from Paediatric Research Enrich the Network Theory of Dystonia

   • Verity M. McClelland, Jean-Pierre Lin

   Pages 1-22

3. Focal Dystonia and the Stress Network: The Role of Stress Vulnerability and Adverse Childhood Experiences in the Development of Musician’s Dystonia

   • Stine Alpheis, Eckart Altenmüller, Daniel S. Scholz

   Pages 23-44

4. Embouchure Dystonia as a Network Disease

   • Johanna Doll-Lee, André Lee, Tobias Mantel, Bernhard Haslinger, Eckart Altenmüller

   Pages 45-59

5. Sensorimotor Incoordination in Musicians’ Dystonia

   • Shinichi Furuya, Takanori Oku

   Pages 61-70

6. Electromyography as a Method for Distinguishing Dystonia in Mice

   • Amanda M. Brown, Elizabeth P. Lackey, Luis E. Salazar Leon, Alejandro G. Rey Hipolito, Jaclyn Beckinghausen, Tao Lin et al.

   Pages 71-91

7. Deep Brain Stimulation of the Interposed Cerebellar Nuclei in a Conditional Genetic Mouse Model with Dystonia

   • Jaclyn Beckinghausen, Sarah G. Donofrio, Tao Lin, Lauren N. Miterko, Joshua J. White, Elizabeth P. Lackey et al.

   Pages 93-117

8. Applications of Transcranial Magnetic Stimulation for Understanding and Treating Dystonia

   • Jessica Frey, Adolfo Ramirez-Zamora, Aparna Wagle Shukla

   Pages 119-139

9. Brain Connectivity in Dystonia: Evidence from Magnetoencephalography

   • Deepal Shah-Zamora, Susan Bowyer, Andrew Zillgitt, Christos Sidiropoulos, Abhimanyu Mahajan

   Pages 141-155

10. Dysfunctional Networks in Functional Dystonia

    • Lucia Ricciardi, Matteo Bologna, Luca Marsili, Alberto J. Espay

    Pages 157-176

11. Neuromodulation in Dystonia – Harnessing the Network

    • Owen Killian, Michael Hutchinson, Richard Reilly

    Pages 177-194

12. The Collicular–Pulvinar–Amygdala Axis and Adult-Onset Idiopathic Focal Dystonias

    • Shameer Rafee, Michael Hutchinson, Richard Reilly

    Pages 195-210

13. Does Pallidal Physiology Determine the Success of Unilateral Deep Brain Stimulation in Cervical Dystonia?

    • Alexey Sedov, Anna Gamaleya, Ulia Semenova, Rita Medvednik, Alexey Tomskiy, Hyder A. Jinnah et al.

    Pages 211-221

14. Clinical Implications of Dystonia as a Neural Network Disorder

    • Giovanni Battistella, Kristina Simonyan

    Pages 223-240

15. Back Matter

    Pages 241-242

    PDF

A recently proposed novel scheme of dystonia suggests that it is a disorder of neural network.  Impairment in any of the “nodes” of the network may result in deficient network activity, causing dystonia.  This book aims to present various experimental evidence supporting the network theory of dystonia.  Dystonia is the abnormal twisting and turning of the organ and associated involuntary oscillations.  Although dystonia is less common than Parkinson’s disease, traumatic brain injury, or stroke, each of these common disorders present with dystonia.  Information regarding the brain regions that may be involved in dystonia is surprisingly limited and often conflicting.    With chapters written by subject matter experts, this is a unique title that focuses on dystonia as a network disorder.  This book would be of interest to basic and clinical researchers with an interest in motor systems and movement disorders.

• Dystonia
• Neural network
• Control systems models
• Pallido-cerebellar network
• Dystonic tremor

• Departments of Neurology and Biomedical Engineering, Case Western Reserve University, Cleveland, USA

  Aasef Shaikh

• Clinical Lecturer, Movement Disorders and Neuromodulation Group, St George’s University of London, London, UK

  Anna Sadnicka

Aasef G Shaikh, MD,PhD is a Penni and Stephen Weinberg Chair in Brain Health at University Hospitals Cleveland. He is a Professor and Vice-Chair for research in Neurology at Case Western Reserve University. Dr Shaikh directs National VA Parkinson Consortium Center at Cleveland VA and is a principal investigator in Daroff DellOsso Oculomotor Laboratory. His interdisciplinary research focuses on motor systems, eye movement and vestibular control. The overarching goal of his research program is to study mechanistic underpinning of complex neurological disorders affecting the eye and head movements and vestibular function.





Dr Anna Sadnicka BSc MBChB MRCP PhD

Anna is a Clinical Lecturer fascinated by the neural control of movement and how this is disturbed in movement disorders.  Her award-winning research combines behavioural experiments, electrophysiology, and computational models to shed light on dystonia mechanism.  She has a particular emphasis on translating her research into novel movement retraining and neuromodulation strategies.