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Neurodevelopmental Pediatrics

Genetic and Environmental Influences

  • Textbook
  • © 2023


  • Explores the interrelationship of genetics, the environment, or both
  • Integrates clinical and research topics, including disease models, for each disorder
  • Provides an overview of the biology, genetics, and epigenetics of brain development

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About this book

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.  

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Table of contents (50 chapters)

  1. Overview of CNS Development and Disorders

  2. Autism Spectrum Disorders

Editors and Affiliations

  • Department of Paediatrics, University of Melbourne, Parkville, Australia

    David D. Eisenstat

  • Department of Medical Genetics, University of British Columbia, Vancouver, Canada

    Dan Goldowitz

  • Department of Pediatrics and School of Population and Public Health, University of British Columbia, Vancouver, Canada

    Tim F. Oberlander

  • Department of Pediatrics, University of Alberta, Edmonton, Canada

    Jerome Y. Yager

About the editors

David D. Eisenstat, MD, MA, FRCPC; Professor, Department of Paediatrics, University of Melbourne; Parkville, Victoria 

Dan Goldowitz, PhD; Scientific Director, NeuroDevNet National Centres of Excellence; Professor and Canada Research Chair; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute; Department of Medical Genetics; University of British Columbia; 950 West 28th Avenue; Vancouver, British Columbia V5Z 4H4

Tim Oberlander, MD, FRCPC; Professor, Department of Pediatrics; BC Children’s Hospital and Child and Family Research Institute; University of British Columbia; 4480 Oak Street; Vancouver, British Columbia V6H 3V4

Jerome Y. Yager, MD, FRCPC; Professor, Department of Pediatrics; Stollery Children’s Hospital; Faculty of Medicine and Dentistry; University ofAlberta

8440 112 Street, NW; Edmonton, Alberta T6G 2R7

Bibliographic Information

  • Book Title: Neurodevelopmental Pediatrics

  • Book Subtitle: Genetic and Environmental Influences

  • Editors: David D. Eisenstat, Dan Goldowitz, Tim F. Oberlander, Jerome Y. Yager

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-20791-4Published: 23 February 2023

  • Softcover ISBN: 978-3-031-20794-5Published: 24 February 2024

  • eBook ISBN: 978-3-031-20792-1Published: 22 February 2023

  • Edition Number: 1

  • Number of Pages: XXI, 832

  • Number of Illustrations: 31 b/w illustrations, 103 illustrations in colour

  • Topics: Pediatrics, Neurology, Human Genetics

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