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  • © 2022

DNA Methyltransferases - Role and Function

  • 2nd edition, extensively updated with novel findings from the past 6 years

  • Discusses novel insights into structure and mechanism of DNA methyltransferases

  • Highlights the newest technologies related to DNA methylation

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1389)

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  • ISBN: 978-3-031-11454-0
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Table of contents (19 chapters)

  1. Front Matter

    Pages i-ix
  2. DNA Methylation in Prokaryotes

    • Josep Casadesús, María A. Sánchez-Romero
    Pages 21-43
  3. Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases

    • Shoji Tajima, Isao Suetake, Kohei Takeshita, Atsushi Nakagawa, Hironobu Kimura, Jikui Song
    Pages 45-68
  4. Enzymology of Mammalian DNA Methyltransferases

    • Renata Z. Jurkowska, Albert Jeltsch
    Pages 69-110
  5. Genetic Studies on Mammalian DNA Methyltransferases

    • Jiameng Dan, Taiping Chen
    Pages 111-136
  6. Structure and Mechanism of Plant DNA Methyltransferases

    • Sarah M. Leichter, Jiamu Du, Xuehua Zhong
    Pages 137-157
  7. DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics

    • Laura Wedd, Robert Kucharski, Ryszard Maleszka
    Pages 159-176
  8. N6-methyladenine: A Rare and Dynamic DNA Mark

    • Zach Klapholz O’Brown, Eric Lieberman Greer
    Pages 177-210
  9. Pathways of DNA Demethylation

    • Wendy Dean
    Pages 211-238
  10. Structure and Function of TET Enzymes

    • Xiaotong Yin, Lulu Hu, Yanhui Xu
    Pages 239-267
  11. Proteins That Read DNA Methylation

    • Ke Liu, Takashi Shimbo, Xiaosheng Song, Paul A. Wade, Jinrong Min
    Pages 269-293
  12. The Role of DNA Methylation and DNA Methyltransferases in Cancer

    • Daniel J. Weisenberger, Ranjani Lakshminarasimhan, Gangning Liang
    Pages 317-348
  13. DNA Methyltransferases and DNA Damage

    • Peter Sarkies
    Pages 349-361
  14. Role of DNMTs in the Brain

    • Can Bora Yildiz, Geraldine Zimmer-Bensch
    Pages 363-394
  15. Inhibitors of DNA Methylation

    • Marie Lopez, Julie Gilbert, Jean Contreras, Ludovic Halby, Paola B. Arimondo
    Pages 471-513
  16. Gene-Targeted DNA Methylation: Towards Long-Lasting Reprogramming of Gene Expression?

    • Fabian M. Cortés-Mancera, Federica Sarno, Désirée Goubert, Marianne G. Rots
    Pages 515-533
  17. DNA Labeling Using DNA Methyltransferases

    • Miglė Tomkuvienė, Edita Kriukienė, Saulius Klimašauskas
    Pages 535-562

About this book

This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years.

Like the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. 

Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.


  • DNA methylation
  • Epigenetics
  • Methyltransferase
  • Demethylation
  • DNA labelling
  • Cancer
  • Therapeutic targets
  • control of gene expression
  • Chromatin
  • Genome imprinting
  • Epigenetic editing
  • Cellular memory
  • Biomarkers
  • Reader proteins
  • Emerging technologies
  • DNA base flipping
  • DNA methylation signature
  • Dnmt1
  • Dnmt3a
  • Dnmt3b

Editors and Affiliations

  • Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Stuttgart, Germany

    Albert Jeltsch

  • School of Biosciences, Division of Biomedicine, Cardiff University, Cardiff, UK

    Renata Z. Jurkowska

About the editors

Prof. Albert Jeltsch is a biochemist who received his PhD in Biochemistry 1994 at the Medical University Hannover (Germany). After PostDoc and Assistant Professorship (2003) at Justus-Liebig University in Giessen, he was appointed as Associate Professor of Biochemistry at Jacobs University Bremen in 2003, where he became Full Professor of Biochemistry in 2006. Prof. Jeltsch moved to the University of Stuttgart in 2011, where he is heading the Department of Biochemistry at the Institute of Biochemistry and Technical Biochemistry. For more than 25 years, the group of Prof. Jeltsch is investigating the structure, mechanism and function of bacterial and mammalian DNA methyltransferases. They have long-standing expertise in the field of rational and evolutionary protein design of DNA interacting enzymes and in the design of chimeric methylation enzymes for epigenome editing and gene regulation in eukaryotic cells. In addition, they study the specificity and activity of protein lysine methyltransferases and methyllysine reading domains and the biological role of protein methylation in cells.

Dr Renata Jurkowska is a molecular biologist with general interests in epigenetics, stem cells and lung biology. She obtained her M.Sc. degree in Biotechnology at Warsaw University (Poland) and went on to complete her PhD in Biochemistry and two postdocs in Germany, where she investigated the specificity and molecular mechanism of mammalian DNA methyltransferases and other epigenetic enzymes for 10 years. In 2015, she joined BioMed X Innovation Center (Germany) as a Principal Investigator, where she worked at the interface between academia and industry, leading a biomedical preclinical project in the field of respiratory medicine and epigenetics. In September 2019 she was appointed Senior Lecturer in the School of Biosciences at Cardiff University, UK. Her current research focuses on understanding how epigenetic regulation drives cellular identity in the healthy lung and how dysregulation of epigenetic processes due to environmental insults contributes to the development of lung diseases. Her group uses epigenomics technologies in combination with molecular biology tools to advance the mechanistic understanding of lung diseases, identify epigenetic biomarkers for diagnosis, and devise novel epigenetic therapeutic strategies.

Bibliographic Information

  • Book Title: DNA Methyltransferases - Role and Function

  • Editors: Albert Jeltsch, Renata Z. Jurkowska

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-031-11453-3Published: 10 November 2022

  • Softcover ISBN: 978-3-031-11456-4Due: 24 November 2023

  • eBook ISBN: 978-3-031-11454-0Published: 09 November 2022

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 2

  • Number of Pages: IX, 562

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Cell Biology, Epigenetics, Medical Genetics, Enzymology

Buying options

eBook USD 219.00
Price excludes VAT (USA)
  • ISBN: 978-3-031-11454-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Hardcover Book USD 279.99
Price excludes VAT (USA)