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Vertebrate Motoneurons

  • Book
  • © 2022

Overview

Editors:
  1. Michael J. O'Donovan

    1. NINDS, NIH, Bethesda, USA

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  2. Mélanie Falgairolle

    1. NINDS, Developmental Neurobiology, National Institutes of Health, Bethesda, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Discusses new findings in motoneuron research
  • Provides information on novel treatments for motoneuron diseases
  • Ideal for graduate students, basic neuroscientists, and clinicians

Part of the book series: Advances in Neurobiology (NEUROBIOL, volume 28)

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About this book

This book aims to provide a comprehensive and timely review of new findings in motoneuron research. Recent findings have revealed that motoneurons are more complex and have more extensive functions than previously imagined. Some of the molecular and genetic pathways that orchestrate the development of motoneurons have been discovered, as have the mechanisms responsible for the selective innervation of muscles by specific pools of motoneurons. These novel findings are revolutionizing ideas about the function of motoneurons and have important implications for motoneuron disease.  

Chapters from several of the foremost figures in the field are included in this book and will emphasize how basic science is the engine driving the discovery of novel treatments for degenerative motoneuron diseases. Cutting edge developments in the use of pluripotent stem cells to correct motoneuron disease will be also be covered.  This book would be useful to students of basic motoneuron physiology, locomotor behavior and motor control. This book would also be of interest to professional neuroscientists, neurologists, and neurosurgeons.

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xii
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  3. Motoneuron Connectivity and Function

    1. Front Matter

      Pages 109-109
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    2. Homeostatic Plasticity of the Mammalian Neuromuscular Junction

      • Kathrin L. Engisch, Xueyong Wang, Mark M. Rich
      Pages 111-130

    3. Diversity of Mammalian Motoneurons and Motor Units

      • Marcin Bączyk, Marin Manuel, Francesco Roselli, Daniel Zytnicki
      Pages 131-150

    4. Synaptic Projections of Motoneurons Within the Spinal Cord

      • Marco Beato, Gary Bhumbra
      Pages 151-168

    5. Recruitment of Motoneurons

      • Vatsala Thirumalai, Urvashi Jha
      Pages 169-190

    6. Electrical Properties of Adult Mammalian Motoneurons

      • Calvin C. Smith, Robert M. Brownstone
      Pages 191-232

    7. The Cellular Basis for the Generation of Firing Patterns in Human Motor Units

      • Obaid U. Khurram, Gregory E. P. Pearcey, Matthieu K. Chardon, Edward H. Kim, Marta García, C. J. Heckman
      Pages 233-258

    8. Motoneuronal Regulation of Central Pattern Generator and Network Function

      • Mélanie Falgairolle, Michael J. O’Donovan
      Pages 259-280

    9. Extraocular Motoneurons and Neurotrophism

      • Angel M. Pastor, Roland Blumer, Rosa R. de la Cruz
      Pages 281-319

  4. Motoneuron Disease

    1. Front Matter

      Pages 321-321
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    2. Motoneuron Diseases

      • Francesco Lotti, Serge Przedborski
      Pages 323-352

    3. Electrical and Morphological Properties of Developing Motoneurons in Postnatal Mice and Early Abnormalities in SOD1 Transgenic Mice

      • Jacques Durand, Anton Filipchuk
      Pages 353-373

    4. From Physiological Properties to Selective Vulnerability of Motor Units in Amyotrophic Lateral Sclerosis

      • Marcin Bączyk, Marin Manuel, Francesco Roselli, Daniel Zytnicki
      Pages 375-394

  5. Back Matter

    Pages 395-400
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Editors and Affiliations

  • NINDS, NIH, Bethesda, USA

    Michael J. O'Donovan

  • NINDS, Developmental Neurobiology, National Institutes of Health, Bethesda, USA

    Mélanie Falgairolle

Bibliographic Information

  • Book Title: Vertebrate Motoneurons

  • Editors: Michael J. O'Donovan, Mélanie Falgairolle

  • Series Title: Advances in Neurobiology

  • DOI: https://doi.org/10.1007/978-3-031-07167-6

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-031-07166-9Published: 07 September 2022

  • Softcover ISBN: 978-3-031-07169-0Published: 08 September 2023

  • eBook ISBN: 978-3-031-07167-6Published: 06 September 2022

  • Series ISSN: 2190-5215

  • Series E-ISSN: 2190-5223

  • Edition Number: 1

  • Number of Pages: XII, 400

  • Number of Illustrations: 17 b/w illustrations, 64 illustrations in colour

  • Topics: Neurosciences

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