Overview
- Reviews C1 compounds as alternative microbial feedstocks
- Critiques key challenges of C1-based bioproduction
- Offers an authoritative perspective on C1-biotechnology
Part of the book series: Advances in Biochemical Engineering/Biotechnology (ABE, volume 180)
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Table of contents (13 chapters)
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Front Matter
Keywords
- One-Carbon Compounds
- C1 feedstocks
- C1 gases
- Alternative microbial feedstocks
- Circular Carbon Economy
- C1-Mixotrophy
- Bioconversion
- Methanol
- methane
- formate
- Acetogenic Production
- Aerobic Carboxydotrophic Bacteria
- Methanotrophic Bacteria
- Synthetic Metylotrophs
- Metabolic Engineering
- Systems Biology
- Synthetic Biology
About this book
This book offers a comprehensive review of the latest developments, challenges and trends in C1-based (one-carbon based) bioproduction, and it presents an authoritative account of one-carbon compounds as promising alternative microbial feedstocks.
The book starts with a perspective on the future of C1 compounds as alternative feedstocks for microbial growth, and their vital role in the establishment of a sustainable circular carbon economy, followed by several chapters in which expert contributors discuss about the recent strategies and address key challenges regarding one or more C1 feedstocks.
The book covers topics such as acetogenic production from C1 feedstocks, aerobic carboxydotrophic bacteria potential in industrial biotechnology, bioconversion of methane to value-added compounds, combination of electrochemistry and biology to convert C1 compounds, and bioprocesses based on C1-mixotrophy. Particular attention is given to the current metabolic engineering, systems biology, and synthetic biology strategies applied in this field.
Editors and Affiliations
About the editors
Prof. An-Ping Zeng was Director of the Institute of Bioprocess and Biosystems Engineering at the Hamburg University of Technology, Germany from April 2006 to March 2022 and recently joined Westlake University in China as Chair Professor for Synthetic Biology and Bioengineering. He got a PhD degree in Biochemical Engineering from Technical University of Braunschweig, Germany. He has extensive research experience in Australia, China, Germany and USA for more than 36 years, among others as research scientist in the former German Research Center for Biotechnology (GBF, now Helmholtz Center for Infection Research), CSIRO and University of Minnesota and as Professor at TU Braunschweig. His recent research covers (1) Industrial biotechnology; (2) Cell culture for proteins and biomaterials; (3) Metabolic engineering and synthetic biology for new enzymes, pathways and microbes using rational and evolutionary approaches; (4) New bioelectrochemical and hybrid systems, especially for useof CO2 and other C1-feedstocks. He has published 300+ papers (Google H-Index 70), edited 5 books and filed 30+ patents. He is Editor-in-Chief of “Engineering in Life Sciences”, and associated editor/editorial board member of seven other journals and book series. He has coordinated several national and international collaborative research projects including the German Research Foundation (DFG) Priority Program 2240 eBiotech. He is member of the German National Academy of Science and Engineering (acatech).
Dr. Nico J. Claassens is an Assistant Professor at the Laboratory of Microbiology at Wageningen University (The Netherlands). A core activity of his group is to perform systems-wide metabolic engineering using novel high-throughput genome editing techniques (including recombineering and CRISPR-Cas) in bacteria. Specifically, his work focuses on engineering synthetic pathways to support the efficient use of next-generation, sustainable feedstocks, including CO2 and one-carbon-substrates, such as formate and methanol. After obtaining his Ph.D. with Prof. John van der Oost at Wageningen University, Nico worked as postdoctoral fellow at the Max Planck Institute Potsdam, Germany with Dr. Arren Bar-Even, supported by a Rubicon fellowship of the Dutch Science Organisation (NWO). During this postdoc in Arren’s lab, Nico and his students demonstrated formatotrophic growth in Cupriavidus necator after the full replacement of the native Calvin cycle by the more ATP-efficient reductive glycine pathway. Furthermore, he characterized the wasteful phosphoglycolate metabolism when C. necator grows via the Calvin cycle on ambient CO2 hydrogen. Together with Arren and other colleagues, he also performed systematic analyses of various biotechnological production strategies using electricity and CO2 as ultimate energy and carbon sources. They considered several mediator molecules to connect the (electro)chemical and biological processes, and identified formate and methanol as highly promising C1-mediators for efficient electromicrobial production. In 2019 he obtained a prestigious NWO-Veni grant for talented junior researchers to continue his research in C1 metabolic engineering at Wageningen University.
Bibliographic Information
Book Title: One-Carbon Feedstocks for Sustainable Bioproduction
Editors: An-Ping Zeng, Nico J. Claassens
Series Title: Advances in Biochemical Engineering/Biotechnology
DOI: https://doi.org/10.1007/978-3-031-06854-6
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-031-06853-9Published: 02 June 2022
Softcover ISBN: 978-3-031-06856-0Published: 03 June 2023
eBook ISBN: 978-3-031-06854-6Published: 31 May 2022
Series ISSN: 0724-6145
Series E-ISSN: 1616-8542
Edition Number: 1
Number of Pages: XII, 407
Topics: Industrial Chemistry/Chemical Engineering, Applied Microbiology, Catalysis, Biotechnology, Biological Techniques, Sustainable Development