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  • Open Access
  • © 2022

The EBMT/EHA CAR-T Cell Handbook

Editors:

  1. Nicolaus Kröger

    1. Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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  2. John Gribben

    1. Bart’s Cancer Institute, Queen Mary University of London, London, UK

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  3. Christian Chabannon

    1. Institut Paoli-Calmettes Comprehensive Cancer Center Aix-Marseille Université School of Medicine, Marseille, France

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  4. Ibrahim Yakoub-Agha

    1. Maladies du Sang, Unité de Thérapie Cellulaire Centre hospitalier-Universitaire de Lille, Lille, France

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  5. Hermann Einsele

    1. Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany

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  • Very first EU CAR-T Cell Handbook

  • Provides an overview of the CAR-T cell technology

  • Finds real application in clinical care

Sections

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Table of contents (47 chapters)

  1. Front Matter

    Pages i-x
    PDF

  2. The Science Behind CAR-T Cells

    1. Front Matter

      Pages 1-1
      PDF

    2. Structure of and Signalling Through Chimeric Antigen Receptor

      • Christian Chabannon, Chiara Bonini
      Pages 3-5Open Access

    3. Genetic Engineering of Autologous or Allogeneic Immune Effector Cells

      • Karim Benabdellah, Simone Thomas, Hinrich Abken
      Pages 7-10Open Access

    4. What Defines a Good Tumour Antigen?

      • Emma C. Morris, J. H. F. (Fred) Falkenburg
      Pages 11-14Open Access

    5. Tumour Escape from CAR-T Cells

      • Leo Rasche, Luca Vago, Tuna Mutis
      Pages 15-22Open Access

    6. CART Initiatives in Europe

      • Alvaro Urbano-Ispizua, Michael Hudecek
      Pages 23-28Open Access

  3. Manufacturing CAR-T Cells: The Supply Chain

    1. Front Matter

      Pages 29-29
      PDF

    4. Point-of-Care Production of CAR-T Cells

      • Julio Delgado, Claire Roddie, Michael Schmitt
      Pages 45-49Open Access

    5. Off-the-Shelf Allogeneic CAR-T Cells or Other Immune Effector Cells

      • Stephane Depil, Waseem Qasim
      Pages 51-54Open Access

  4. Clinical Indications for CAR-T Cells

    1. Front Matter

      Pages 55-55
      PDF

    2. Paediatric Acute Lymphoblastic Leukaemia (ALL)

      • Peter Bader, Franco Locatelli, Christina Peters
      Pages 57-59Open Access

    3. Adult Acute Lymphoblastic Leukaemia

      • Elad Jacoby, Nicola Gökbuget, Arnon Nagler
      Pages 61-66Open Access

    4. Diffuse Large B Cell Lymphoma and Primary Mediastinal Lymphoma

      • Bertram Glass, Marie José Kersten
      Pages 67-74Open Access

    5. Mantle Cell Lymphoma

      • Noel Milpied, Martin Dreyling
      Pages 75-77Open Access

    6. Chronic Lymphocytic Leukaemia

      • Olivier Tournilhac, Peter Dreger
      Pages 79-82Open Access

    7. Indolent Lymphomas

      • Franck Morschhauser, Pier Luigi Zinzani
      Pages 83-86Open Access

    8. Multiple Myeloma

      • Ibrahim Yakoub-Agha, Hermann Einsele
      Pages 87-90Open Access
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About this book

This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its  application in clinical care, to enhance readers’ knowledge and practice skills.

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Keywords

  • Biology CAR-T
  • Manufacturing CAR-T
  • Indications CAR-T
  • Complications CAR-T
  • Access CAR-T
  • Open Access
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Editors and Affiliations

  • Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Nicolaus Kröger

  • Bart’s Cancer Institute, Queen Mary University of London, London, UK

    John Gribben

  • Institut Paoli-Calmettes Comprehensive Cancer Center Aix-Marseille Université School of Medicine, Marseille, France

    Christian Chabannon

  • Maladies du Sang, Unité de Thérapie Cellulaire Centre hospitalier-Universitaire de Lille, Lille, France

    Ibrahim Yakoub-Agha

  • Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany

    Hermann Einsele

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About the editors

Nicolaus Kröger MD, is the current EBMT President, Professor of Medicine and Medical Director of the Department of Stem Cell Transplantation at the University Medical Center, Hamburg - Eppendorf, Germany 

John G. Gribben, MD DSc FRCP FRCPath, FMedSci, is the Past President of EHA, Professor of Medical Oncology and Director of Stem Cell Transplantation at Saint Bartholomew's Hospital, Queen Mary School of Medicine, University of London, UK

Christian Chabannon, MD, PhD, is the current chair of the Cellular Therapy & Immunobiology Working Party (CTIWP) of the EBMT, is the Head and Qualified Person of the Cell Collection and Cell Processing Facility at Institut Paoli-Calmettes, the Coordinator of the "Centre d’Investigations Cliniques en Biothérapies de Marseille", and a Professor of Cell Biology at Aix-Marseille University, France

Ibrahim Yakoub-Agha, MD, PhD, is the current chair of the Chronic Malignancies Working Party of the EBMT and holds the position of coordinating professor for the Department of Hematology at Lille Faculty of Medicine, France

Hermann Einsele, MD, FRCP, is Full Professor of Internal Medicine and has been Director of the Department of Internal Medicine II of the University Hospital Würzburg, Germany

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Bibliographic Information

  • Book Title: The EBMT/EHA CAR-T Cell Handbook

  • Editors: Nicolaus Kröger, John Gribben, Christian Chabannon, Ibrahim Yakoub-Agha, Hermann Einsele

  • DOI: https://doi.org/10.1007/978-3-030-94353-0

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2022

  • License: CC BY

  • Softcover ISBN: 978-3-030-94352-3Published: 08 February 2022

  • eBook ISBN: 978-3-030-94353-0Published: 07 February 2022

  • Edition Number: 1

  • Number of Pages: X, 237

  • Number of Illustrations: 17 b/w illustrations, 9 illustrations in colour

  • Topics: Nursing, Internal Medicine, Surgery

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Softcover Book USD 49.99
Price excludes VAT (USA)
Learn about institutional subscriptions