This book highlights the latest research on distributed computing and artificial intelligence. DCAI 2021 is a forum to present applications of innovative techniques for studying and solving complex problems in artificial intelligence and computing areas. The present edition brings together past experience, current work and promising future trends associated with distributed computing, artificial intelligence and their application in order to provide efficient solutions to real problems. This year’s technical program will present both high quality and diversity, with contributions in well-established and evolving areas of research. Specifically, 55 papers were submitted to main track and special sessions, by authors from 24 different countries representing a truly “wide area network” of research activity. Moreover, DCAI 2021 Special Sessions have been a very useful tool in order to complement the regular program with new or emerging topics of particular interest to the participating community. The technical program of the Special Sessions of DCAI 2021 has selected 23 papers. We would like to thank all the contributing authors, the members of the Program Committees, the sponsors (IBM, Armundia Group, EurAI, AEPIA, APPIA, CINI, OIT, UGR, HU, SCU, USAL, AIR Institute and UNIVAQ) and the Organizing Committee of the University of Salamanca for their hard and highly valuable work.