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Cardiomyocytes in Health and Disease

  • Book
  • © 2021

Overview

Authors:
  1. Chandrasekharan C. Kartha

    1. Amrita Institute of Medical Sciences, Cochin, India

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  • Provides concise yet comprehensive reviews of the developments in biology and pathobiology of the cardiomyocyte

  • Acts as a useful primer for those to set foot in cardiovascular research

  • Is appropriate for cardiologists, cardiovascular surgeons, and cardiovascular scientists

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xxvii
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  2. Normal Cardiomyocyte and its Growth

    1. Front Matter

      Pages 1-1
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    2. Structure and Function of Cardiomyocyte

      • Chandrasekharan C. Kartha
      Pages 3-12

    3. Development of the Cardiomyocyte

      • Chandrasekharan C. Kartha
      Pages 13-23

    4. Cell Cycle Regulation in Cardiomyocytes

      • Chandrasekharan C. Kartha
      Pages 25-39

    5. Cardiac Fibroblast and Cardiomyocyte Growth

      • Chandrasekharan C. Kartha
      Pages 41-53

    6. Role of Endocardium and Epicardium in Generation of Cardiomyocytes

      • Chandrasekharan C. Kartha
      Pages 55-61

    7. Cardiomyocytes in the Mammalian Adult Heart

      • Chandrasekharan C. Kartha
      Pages 63-72

    8. Energy Metabolism in Cardiomyocyte

      • Chandrasekharan C. Kartha
      Pages 73-92

  3. Cardiomyocyte Responses

    1. Front Matter

      Pages 93-93
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    2. Response of Cardiomyocytes to Mechanical Stress

      • Chandrasekharan C. Kartha
      Pages 95-114

    3. Cardiomyocyte Responses to Hormones

      • Chandrasekharan C. Kartha
      Pages 115-144

    4. Sequelae of Genetic Defects in Cardiomyocytes

      • Chandrasekharan C. Kartha
      Pages 145-168

    5. Response and Effects of Cardiomyocyte Progenitors in the Infarcted Heart

      • Chandrasekharan C. Kartha
      Pages 169-183

  4. Cardiomyocyte Aging and Death

    1. Front Matter

      Pages 185-185
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    2. Cardiomyocyte Senescence

      • Chandrasekharan C. Kartha
      Pages 187-205

    3. Mechanisms of Cardiomyocyte Death

      • Chandrasekharan C. Kartha
      Pages 207-225

    4. Cardiomyocyte Response to Ischemic Injury

      • Chandrasekharan C. Kartha
      Pages 227-244

    5. Cardiomyocytes in Heart Failure

      • Chandrasekharan C. Kartha
      Pages 245-255

  5. Cardiomyocyte Regeneration

    1. Front Matter

      Pages 257-257
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Keywords

About this book

This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon. 

Authors and Affiliations

  • Amrita Institute of Medical Sciences, Cochin, India

    Chandrasekharan C. Kartha

Bibliographic Information

  • Book Title: Cardiomyocytes in Health and Disease

  • Authors: Chandrasekharan C. Kartha

  • DOI: https://doi.org/10.1007/978-3-030-85536-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-85535-2Published: 14 September 2021

  • Softcover ISBN: 978-3-030-85538-3Published: 15 September 2022

  • eBook ISBN: 978-3-030-85536-9Published: 13 September 2021

  • Edition Number: 1

  • Number of Pages: XXVII, 345

  • Number of Illustrations: 1 b/w illustrations, 43 illustrations in colour

  • Topics: Physiology, Cardiology, Regenerative Medicine/Tissue Engineering, Biomedicine, general

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