Skip to main content
SpringerLink
Log in
Book cover

Analysis of Data from Randomized Controlled Trials

A Practical Guide

  • Textbook
  • © 2021

Overview

Authors:
  1. Jos W.R. Twisk

    1. Amsterdam UMC, Amsterdam, The Netherlands

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • Gives an overview of data analysis for Randomized Controlled Trials for non-mathematical researchers
  • Includes many different RCT designs
  • Provides extensive examples and datasets for the statistical methods discussed in the book

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (11 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Introduction

    • Jos W. R. Twisk
    Pages 1-3

  3. Analysis of RCT Data with One Follow-Up Measurement

    • Jos W. R. Twisk
    Pages 5-13

  4. Analysis of RCT Data with More Than One Follow-Up Measurement

    • Jos W. R. Twisk
    Pages 15-47

  5. Analysis of Data from a Cluster RCT

    • Jos W. R. Twisk
    Pages 49-59

  6. Analysis of Data from a Cross-Over Trial

    • Jos W. R. Twisk
    Pages 61-72

  7. Analysis of Data from a Stepped Wedge Trial

    • Jos W. R. Twisk
    Pages 73-105

  8. Analysis of Data from an N-of-1 Trial

    • Jos W. R. Twisk
    Pages 107-113

  9. Dichotomous Outcomes

    • Jos W. R. Twisk
    Pages 115-135

  10. What to Do When Only a Baseline Measurement Is Available

    • Jos W. R. Twisk
    Pages 137-150

  11. Sample Size Calculations

    • Jos W. R. Twisk
    Pages 151-155

  12. Miscellaneous

    • Jos W. R. Twisk
    Pages 157-161

  13. Back Matter

    Pages 163-168
    Download chapter PDF
Back to top

Keywords

About this book

This book provides a practical guide to the analysis of data from randomized controlled trials (RCT). It gives an answer to the question of how to estimate the intervention effect in an appropriate way. This problem is examined for different RCT designs, such as RCTs with one follow-up measurement, RCTs with more than one follow-up measurement, cluster RCTs, cross-over trials, stepped wedge trials, and N-of-1 trials. The statistical methods are explained in a non-mathematical way and are illustrated by extensive examples. All datasets used in the book are available for download, so readers can reanalyse the examples to gain a better understanding of the methods used. Although most examples are taken from epidemiological and clinical studies, this book is also highly recommended for researchers working in other fields.

Authors and Affiliations

  • Amsterdam UMC, Amsterdam, The Netherlands

    Jos W.R. Twisk

About the author

Jos Twisk is a professor in applied biostatistics at the Amsterdam University Medical Centre, where he is the director of the Epidemiology Master Program and head of the Expertise Centre for Applied Longitudinal Data Analysis. He has written several textbooks varying from the basic principles of applied biostatistics to applied longitudinal data analysis and applied mixed model analysis. His main activities include applied methodological research, consulting and teaching courses on mixed model analysis, longitudinal data analysis, multilevel analysis, applied basic statistics and the analysis of RCT data. He has authored and co-authored more than 1000 peer-reviewed international papers.

Bibliographic Information

  • Book Title: Analysis of Data from Randomized Controlled Trials

  • Book Subtitle: A Practical Guide

  • Authors: Jos W.R. Twisk

  • DOI: https://doi.org/10.1007/978-3-030-81865-4

  • Publisher: Springer Cham

  • eBook Packages: Mathematics and Statistics, Mathematics and Statistics (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-81864-7Published: 16 October 2021

  • Softcover ISBN: 978-3-030-81867-8Published: 16 October 2022

  • eBook ISBN: 978-3-030-81865-4Published: 15 October 2021

  • Edition Number: 1

  • Number of Pages: IX, 168

  • Number of Illustrations: 17 b/w illustrations

  • Topics: Statistical Theory and Methods, Biomedicine, general, Biostatistics

Publish with us

Policies and ethics

Back to top

Search

Navigation