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Electroporation in Veterinary Oncology Practice

Electrochemotherapy and Gene Electrotransfer for Immunotherapy

  • Book
  • © 2021

Overview

Editors:
  1. Joseph A. Impellizeri

    1. Veterinary Oncology Services, PLLC, New York, USA

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  • The first reference on electroporation for veterinarians
  • Expand your knowledge on a range of new treatments options in oncology
  • Describes control of easily accessible lesions, e.g. cutaneous metastasis, intraluminal and deep-seated tumors
  • Presented in a practical approach
  • Learn the benefits of gene electrotransfer, including Telomerase, HER2 and IL-12 immunotherapy
  • Informs about the proper timing, usage and combination of Electrochemotherapy as a multi-modality component

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xii
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  2. Technology and Science of Electroporation: Fundamentals

    1. Front Matter

      Pages 1-1
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    2. Electroporation: Technology and Science

      • Marie-Pierre Rols, Muriel Golzio, Justin Teissié
      Pages 3-19

    3. Electrodes and Electric Field Distribution in Clinical Practice

      • Helena Cindrič, Bor Kos, Damijan Miklavčič
      Pages 21-59

  3. Therapeutic Applications with Electroporation in Veterinary Oncology Practice

    1. Front Matter

      Pages 61-61
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    2. Electrochemotherapy in Veterinary Oncology

      • Nataša Tozon, Nina Milevoj, Joseph Impellizeri
      Pages 63-112

    3. Treating Mast Cell Tumors with Electrochemotherapy

      • Petra Simčič, Alessio Pierini, George Lubas
      Pages 113-135

    4. Electrochemotherapy for the Treatment of Transitional Cell Carcinoma in Dogs

      • M. M. M. Rangel, D. O. H. Suzuki
      Pages 137-144

    5. Calcium Electroporation in Veterinary Medicine

      • Stine K. Frandsen, Martin S. Thoefner, Julie Gehl
      Pages 145-164

    6. Irreversible Electroporation Applications

      • Brittanie Partridge, Melvin F. Lorenzo, Nikolaos Dervisis, Rafael V. Davalos, John H. Rossmeisl
      Pages 165-204

    7. Electrochemotherapy as a Multi-Modality Component of Cancer Treatment: Combinations with Surgery, Cryosurgery, Radiation Therapy, and Chemotherapy

      • M. Tellado, F. Maglietti, J. Impellizeri
      Pages 205-216

  4. Gene-Electrotransfer and Immunotherapy Applications with Electroporation

    1. Front Matter

      Pages 217-217
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    2. Gene Electrotransfer

      • Loree C. Heller, Richard Heller
      Pages 219-234

    3. Immunotherapy Applications (Telomerase and HER2) with Gene Electrotransfer

      • Antonella Conforti, Joseph Impellizeri, Luigi Aurisicchio
      Pages 235-252

    4. Interleukin-12 Gene Electrotransfer in Veterinary Oncology

      • Ursa Lampreht Tratar, Natasa Tozon, Nina Milevoj, Gregor Sersa, Ana Nemec, Katja Ursic et al.
      Pages 253-276

    5. Canine Melanoma and Osteosarcoma Immunotherapy by Means of In Vivo DNA Electroporation

      • Lidia Tarone, Paolo Buracco, Federica Cavallo, Federica Riccardo
      Pages 277-304

  5. Evolution of the Field and New Applications with Electroporation-Based Treatments: Outlook

    1. Front Matter

      Pages 305-305
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    2. Electrodes for Unique Anatomical Access in Electroporation

      • F. Maglietti, M. Tellado, J. Impellizeri
      Pages 307-319

    3. New Electrodes and Treatment Planning for Deep-Seated and Intraluminal Localized Tumors

      • Roberta Fusco, Valeria D’Alessio, Francesco Izzo, Raffaele Palaia, Ruggero Cadossi
      Pages 321-338

    4. Advancing Electroporation Systems

      • Roberta Fusco, Elio Di Bernardo, Valeria D’Alessio, Ruggero Cadossi, Matteo Cadossi
      Pages 339-352
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Keywords

About this book

This is the first edited collection on veterinary applications of electroporation. Written by an international team of experts, this book presents worldwide emerging therapy options for cancer treatments in veterinary oncology practice.

Electroporation offers a precision tool to target cancer cells without destroying surrounding tissue structures. The opening of tumor cell membranes facilitates local control of solid tumors either through the delivery of chemotherapeutics or by direct ablation of tissues using electric fields. In addition, transfer of gene-based products into the cancer cells can be used for genetic vaccination to achieve systemic responses and cancer control.

Readers will discover valuable reference texts for practitioner education, including chapters on electrodes for unique anatomical access and treatment planning for deep-seated tumors, different immunotherapy applications with gene electrotransfer, calcium electroporation, irreversible electroporation applications and combinations with other common treatments such as surgery, radiation therapy and chemotherapy.

Therapy options with electroporation are gaining interest around the world in both human and veterinary oncology, making this book valuable for oncologists, surgeons, primary care veterinarians, residents, interns and students at veterinary schools, where teaching of Electrochemotherapy will become part of the curriculum. Featuring cross-disciplinary authorship, this work further contributes to advances in comparative medicine and translation research in support of the One Health concept.


Editors and Affiliations

  • Veterinary Oncology Services, PLLC, New York, USA

    Joseph A. Impellizeri

About the editor

Dr. Joseph A. Impellizeri DVM, DACVIM (Oncology), MRCVS is the Chief Medical Officer of Veterinary Oncology Services, PLLC, New York, USA. after  graduating from the College of Veterinary Medicine at Cornell University, Dr. Impellizeri completed a small animal medical and surgical internship at the College of Veterinary Medicine and Biological Sciences at Colorado State University. After 5 years in private practice and emergency critical care, he completed his Oncology Residency and became a Diplomate of the American College of Veterinary Internal Medicine, Sub-Specialty of Oncology. An advocate of advancing cancer treatments in pets and people, Dr. Impellizeri holds an academic position as a Visiting Scholar in the Department of Biology at Vassar College in Poughkeepsie, NY. And is a member of the Royal college of veterinary surgeons.  Dr. Impellizeri created the Barrymore Center for Advanced Cancer Care specializing in U.S. based Electrogenetherapy/Electrochemotherapy comprising cancer immunotherapy and localized targeted therapies to battle cancer in pets. Dr. Impellizeri is a frequent lecturer across the globe and continues to provide consults and treatments throughout the United States.

Bibliographic Information

  • Book Title: Electroporation in Veterinary Oncology Practice

  • Book Subtitle: Electrochemotherapy and Gene Electrotransfer for Immunotherapy

  • Editors: Joseph A. Impellizeri

  • DOI: https://doi.org/10.1007/978-3-030-80668-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-80667-5Published: 21 November 2021

  • eBook ISBN: 978-3-030-80668-2Published: 20 November 2021

  • Edition Number: 1

  • Number of Pages: XII, 352

  • Number of Illustrations: 4 b/w illustrations, 55 illustrations in colour

  • Topics: Veterinary Medicine/Veterinary Science, Animal Physiology, Biomedicine, general, Cancer Research, Immunology

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