Early Osteoarthritis

1. Front Matter

   Pages i-ix

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2. Early OA Definition, Epidemiology and Risk

   1. Front Matter

      Pages 1-1

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   2. Definition of Early Osteoarthritis

      • Henning Madry

      Pages 3-15

   3. MRI of Early OA

      • Benedikt Hager, Marcus Raudner, Vladimir Juras, Olgica Zaric, Pavol Szomolanyi, Markus Schreiner et al.

      Pages 17-26

   4. MRI Relaxometry as Early Measures of OA

      • Xiaojuan Li, Carl S. Winalski, Thomas M. Link

      Pages 27-37

   5. Epidemiology of Post-traumatic Osteoarthritis of the Lower Extremity: Premature Aging of Youthful Joints

      • Kaetlyn R. Arant, Jeffrey N. Katz

      Pages 39-49

   6. Economic Aspects of Early Osteoarthritis

      • Prem N. Ramkumar, Bryan C. Luu, Justin T. Maas, Morgan H. Jones

      Pages 51-61

   7. Early Osteoarthritis: Frequency, Epidemiology, and Cost of ACL Injuries

      • Hailey P. Huddleston, Stephanie E. Wong, Adam B. Yanke

      Pages 63-72

   8. The Human Anterior Cruciate Ligament Injury Model of Early Osteoarthritis

      • Cale A. Jacobs, Emily R. Hunt

      Pages 73-81

3. Basic Science of Early OA

   1. Front Matter

      Pages 83-83

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   2. Biomechanics of Instability and Its Relationship to OA

      • Benjamin B. Rothrauff, Michael A. Fox, Ryan S. Murray, Philipp W. Winkler, Volker Musahl

      Pages 85-102

   3. Early OA Following Synovial Joint Fracture

      • Don Anderson, James Martin, J. Lawrence Marsh, Jessica Goetz, Mitchell Coleman, Todd McKinley et al.

      Pages 103-119

   4. Inflammation After Anterior Cruciate Ligament Injury

      • Emily R. Hunt, Julie P. Burland, Christian Lattermann, Cale A. Jacobs

      Pages 121-129

   5. T Cells in Early Osteoarthritis

      • Laura E. Keller, Lisa A. Fortier, Elia D. Tait Wojno

      Pages 131-145

   6. Monocytes, Macrophages and Joint Inflammation in Osteoarthritis

      • Renee T. Ormsby, Julia F. Charles

      Pages 147-169

   7. Mesenchymal Stromal Cells and Extracellular Vesicles

      • Michelle L. Delco, Nikita Srivastava

      Pages 171-193

4. Treatment of Early OA

   1. Front Matter

      Pages 195-195

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   2. Role of Injection Therapy in Early Osteoarthritis: Cortisone, Viscosupplement, PRP?

      • Giuseppe Filardo, Giorgio di Laura Frattura, Davide Previtali, Angelo Boffa, Christian Candrian

      Pages 197-206

   3. The Current Role of Stem Cell Therapy and iPS Cells

      • George Jacob, Kazunori Shimomura, David A. Hart, Norimasa Nakamura

      Pages 207-219

   4. Fat-Derived Stem Cells

      • Francesca Libonati, Alessandra Colombini, Carlotta Perucca Orfei, Laura de Girolamo

      Pages 221-230

Early osteoarthritis is novel topic for orthopedic surgeons and its process begins immediately after joint injury. The mechanical restoration of the joint surface or ligamentous stability is not sufficient to restore the homeostatic environment in the joint, and this leads to osteoarthritis, despite mechanical stability and alignment. This book sheds light on the various mechanisms and systems involved in the gradual decline of the injured joint toward manifest osteoarthritis.

Published in collaboration with ISAKOS, this volume appeals to all stakeholders in surgical orthopaedics and sports medicine.

• Articular cartilage
• chronic joint inflammation
• macrophages
• synovitis
• biomarker

• Brigham and Women’s Hospital Harvard Medical School, Boston, USA

  Christian Lattermann

• Zentrum fur Experimentelle Orthopädie, Universitätsklinikum des Saarlandes, Homburg, Germany

  Henning Madry

• Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan

  Norimasa Nakamura

• Department of Biomedical Sciences, Humanitas Research Hospital, Rozzano, Italy

  Elizaveta Kon

Christian Lattermann has recently been appointed to the Brigham and Women’s Hospital at Harvard Medical School as Chief of Sports Medicine and Director of the Cartilage Repair Center. Until 2018 he was Professor and Vice Chair for Orthopaedic Surgery and Research at the University of Kentucky (UK), where he is the founder and Director of the Center for Cartilage Repair and Restoration. He is an expert in cartilage repair, outcomes research and clinical trials.

Henning Madry is a clinician-scientist, a tenured Professor and Chair of Orthopedic Research and Director of the Center of Experimental Orthopedics at Saarland University in Germany. He is the founding Editor-in-Chief of the Journal of Experimental Orthopaedics, the basic science journal of the European Society for Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA). As a clinically active orthopedic surgeon, he has special expertise in regenerative treatments for cartilage defects and osteoarthritis. His research translates novel molecular, cell biology and tissue engineering approaches into clinical applications in orthopedic surgery with a focus on translational aspects of osteochondral regeneration.

Norimasa Nakamura is Professor at the Institute for Medical Science in Sports at Osaka Health Science University and the Global Center for Medical Engineering and Informatics at Osaka University. He is an orthopedic surgeon at the Osaka University Hospital, specializing in arthroscopic surgery and sports medicine. His current main interest is the development of three-dimensional tissue engineered constructs derived from various stem cells in joint tissue repair and regeneration. Norimasa Nakamura has been involved in the ICRS (serving as the President from 2015 to 2016) and ISAKOS (member of the board of directors from 2009 to 2013, the Chair of the scientific committee from 2013 to 2015, the Chair of the publication committee since 2019).

Elizaveta Kon is an Associated Professor at Humanitas University, Milan, an orthopedic surgeon at the Center of Functional and Biological Reconstruction of the knee, Humanitas Research Hospital, Milan, and 2nd Vice President of the International Cartilage Regeneration & Joint Preservation Society (ICRS).

Until 2017 she was Director of the Nano-Biotecnology Laboratory and an orthopedic surgeon at Rizzoli Orthopedic Institute, and Assistant Professor at University of Bologna. She has coordinated numerous research projects and clinical trials regarding biotechnology applications in orthopedics in the framework of Italian and European research.