Overview
- Provides a comprehensive overview on biosynthesis, regulation, functionality, analytics, and applications of immunoglobulin glycosylation
- Covers automatization and bioinformatics in high-throughput analytical settings
- Provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy
- Discusses the relevance of immunoglobulin G glycosylation in light of the SARS CoV 2 pandemic
- Written by an international team of accomplished scientists from academia and industry
Part of the book series: Experientia Supplementum (EXS, volume 112)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (19 chapters)
-
Front Matter
-
Analytical Methods
-
Front Matter
-
-
Biosynthesis and Regulation
-
Front Matter
-
-
Effector Functions and Diseases
-
Front Matter
-
-
Applications
-
Front Matter
-
Keywords
About this book
This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy.
Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols.Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike.
Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Editors and Affiliations
About the editor
Marija Pezer received her PhD in Molecular Biology from the University of Zagreb, Croatia, in 2013. She currently works at Genos Glycoscience Research Laboratory, Croatia, where she is investigating the biomarker potential of immunoglobulin G glycosylation patterns in different pathological and physiological states. The Genos lab has performed over 150,000 total plasma and IgG N-glycome analyses (world’s No. 1). She is also the Head of product development for GlycanAge – the first glycan-based test for biological age.
Bibliographic Information
Book Title: Antibody Glycosylation
Editors: Marija Pezer
Series Title: Experientia Supplementum
DOI: https://doi.org/10.1007/978-3-030-76912-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-76911-6Published: 23 October 2021
Softcover ISBN: 978-3-030-76914-7Published: 24 October 2022
eBook ISBN: 978-3-030-76912-3Published: 22 October 2021
Series ISSN: 1664-431X
Series E-ISSN: 2504-3692
Edition Number: 1
Number of Pages: XII, 591
Number of Illustrations: 10 b/w illustrations, 56 illustrations in colour
Topics: Immunology, Pharmacology/Toxicology, Biomedicine, general, Analytical Chemistry, Biotechnology