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  • © 2021

Epitranscriptomics

  • Provides a comprehensive review of the chemical, regulatory, and physiological mechanisms of RNA modification

  • Unravels the role of RNA modification in development, tissue homeostasis and disease

  • Reviews recent advances in a novel, vast and exciting research area

  • Covers bioinformatics approaches and wet lab methodologies

Part of the book series: RNA Technologies (RNATECHN, volume 12)

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eBook USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-71612-7
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  • Readable on all devices
  • Own it forever
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  • Tax calculation will be finalised during checkout
Softcover Book USD 199.99
Price excludes VAT (USA)
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Table of contents (22 chapters)

  1. Front Matter

    Pages i-x
  2. The Emerging Neuroepitranscriptome

    • Andrew M. Shafik, Emily G. Allen, Peng Jin
    Pages 1-22
  3. RNA Modifications in Neurodegenerations

    • Eleonora Calzoni, Chiara Argentati, Alessio Cesaretti, Nicolò Montegiove, Ilaria Tortorella, Martina Bazzucchi et al.
    Pages 23-77
  4. Epitranscriptomic Signatures in Neural Development and Disease

    • Shikha Sharma, Nibedita Lenka
    Pages 79-120
  5. Epitranscriptomics and Diseases

    • Masamitsu Konno, Hideshi Ishii
    Pages 121-140
  6. Epitranscriptomics Markers Regulate the Infection by RNA Viruses

    • Vassiliki Stamatopoulou, Apostolos Zaravinos
    Pages 141-163
  7. Epitranscriptomic Modifications and How to Find Them

    • Megan L. Van Horn, Anna M. Kietrys
    Pages 165-196
  8. Regulation of RNA Stability Through RNA Modification

    • Kentaro Kawata, Nobuyoshi Akimitsu
    Pages 217-246
  9. Deciphering RNA Methylation in Cancer

    • Daniela Barros-Silva, Elena S. Martens-Uzunova, Carmen Jerónimo
    Pages 247-266
  10. Roles of m6A RNA Modification in Normal Development and Disease

    • Mohammad Burhan Uddin, Zhishan Wang, Chengfeng Yang
    Pages 267-308
  11. N6-Methyladenosine in the Heart

    • Vivien Kmietczyk, Ellen Malovrh, Mirko Völkers
    Pages 309-323
  12. From m6A to Cap-Adjacent m6Am and their Effects on mRNAs

    • Trinh T. Tat, Daniel L. Kiss
    Pages 325-351
  13. RNA m6A Modification: The Mediator Between Cellular Stresses and Biological Effects

    • Lingfang Wang, Yasen Maimaitiyiming, Kunhui Su, Chih-Hung Hsu
    Pages 353-390
  14. Regulation of RNA Methylation by TET Enzymes

    • Kelly M. Banks, Todd Evans
    Pages 423-433
  15. Discovery, Processing, and Potential Role of Noncanonical Caps in RNA

    • Hao Hu, Nora Flynn, Xuemei Chen
    Pages 435-469
  16. ADAR-Mediated RNA Editing and Its Therapeutic Potentials

    • Beatrice Casati, Dimitra Stamkopoulou, Rafail Nikolaos Tasakis, Riccardo Pecori
    Pages 471-503
  17. Mechanisms and Clinical Applications of RNA Pseudouridylation

    • Pedro Morais, Hironori Adachi, Jonathan L. Chen, Yi-Tao Yu
    Pages 505-526

About this book

This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics.

This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis.

Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.

Keywords

  • Epitranscriptome
  • RNA methylation
  • RNA modifications
  • RNA epigenetics
  • Neuroepitranscriptome
  • RNA editing
  • Posttranscriptional modification
  • Cancer
  • RNA viruses

Editors and Affiliations

  • Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Stefan Jurga

  • Nanobiomedical Center of the Adam Mickiewicz University, Poznań and, Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland

    Jan Barciszewski

About the editors

Professor Stefan Jurga conducts interdisciplinary scientific research in the field of nanoscience and nanotechnology, covering the physical, chemical, biological and medical sciences. He has authored over 270 publications in the interdisciplinary database Journal Citation Reports. He has served as a Visiting Professor at e.g. Cornell University, North Carolina State University, and the University of South Africa in Pretoria. Professor Jurga was a laureate of the Alexander von Humboldt Foundation and a scholarship holder at the Max Planck Institute for Polymer Research in Mainz (Germany). He has also worked at the University of Illinois at Urbana Champaign, at the Józef Stefan Institute in Ljubljana, and at many other international scientific institutions.

Professor Jurga has served as Vice-Rector and Rector of the Adam Mickiewicz University Poznań (AMU), and also created the interdisciplinary NanoBioMedical Center at the AMU, which he has been the director of since 2010. From 2005 to 2007 he was appointed as the Under Secretary and Secretary of State for research and higher education at the Ministry of Education and Science and the Ministry of Science and Higher Education.

Jan Barciszewski is a Professor at Adam Mickiewicz University (AMU) in Poznań, Poland and at the Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland where he has worked since 1974. He studied organic chemistry at the AMU. During his PhD studies he worked on the structure and function of modified bases and nucleoside sequences of plant phenylalanine specific transfer ribonucleic acid (tRNA), including cytokinins. He was subsequently granted a Doctor of Science degree for his work on the properties of plant tRNAs and aminoacyl-tRNA synthetases. In the 1990s he began working on the diagnosis and therapy of brain tumors. He developed a new method for the transformation of plant mitochondria based on catalytic RNAs, and is currently involved in studies on a new type of catalytic RNAs (enantiomeric ribozymes) for efficient RNA target cleavage in vivo, as well as the search for new anti-aging agents.

Bibliographic Information

  • Book Title: Epitranscriptomics

  • Editors: Stefan Jurga, Jan Barciszewski

  • Series Title: RNA Technologies

  • DOI: https://doi.org/10.1007/978-3-030-71612-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-71611-0

  • Softcover ISBN: 978-3-030-71614-1

  • eBook ISBN: 978-3-030-71612-7

  • Series ISSN: 2197-9731

  • Series E-ISSN: 2197-9758

  • Edition Number: 1

  • Number of Pages: X, 632

  • Number of Illustrations: 6 b/w illustrations, 84 illustrations in colour

  • Topics: Epigenetics, RNA Metabolism, Biological Chemistry, Bioinformatics

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-71612-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 199.99
Price excludes VAT (USA)
Hardcover Book USD 199.99
Price excludes VAT (USA)