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  • © 2021


Facts and Prospects


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  • Examines the physiology of the immune system in the brain, and the pathophysiology of the immune system in psychiatric disorders

  • Offers a comprehensive description of the state of the art of the role of immune dysfunction in various disorders and cutting edge innovative therapies based on immune mechanisms

  • Appeals to psychiatrists, students and researchers across neurosciences, psychiatry and immunology, and in industry

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USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-71229-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
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  • Tax calculation will be finalised during checkout
Hardcover Book
USD 179.99
Price excludes VAT (USA)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xi
  2. Immune Mechanisms and Pathways Leading to Psychiatric Disorders

    1. Front Matter

      Pages 1-1
    2. Autoimmune Diseases and Infections as Risk Factors for Mental Disorders

      • Sonja Orlovska-Waast, Michael Eriksen Benros
      Pages 3-16
    3. The Life-Long Consequences of Prenatal and Childhood Stress on the Innate and Adaptive Immune System

      • Juliette Giacobbe, Carmine M. Pariante, Alessandra Borsini
      Pages 17-40
    4. Immunity as a Common Risk Pathway for Psychiatric and Medical Comorbidity

      • Joshua D. Rosenblat, Roger S. McIntyre
      Pages 41-50
    5. Magnetic Resonance Imaging Measures of Neuroinflammation in Psychiatry

      • Maria A. Di Biase, Jordan A. Chad, Ofer Pasternak
      Pages 51-65
    6. Cytokines as Biomarkers in Psychiatric Disorders: Methodological Issues

      • Olfa Khalfallah, Susana Barbosa, Emanuela Martinuzzi, Laetitia Davidovic, Nicolas Glaichenhaus
      Pages 67-83
    7. Pro-inflammatory Cytokines and the Depressive Phenotype

      • Feyza Aricioglu, Ceren Sahin Ozkartal, Brian E. Leonard
      Pages 85-108
    8. Role of the T-Cell Network in Psychiatric Disorders

      • Monojit Debnath, Charles L. Raison, Michael Maes, Michael Berk
      Pages 109-132
    9. Microglia and Psychiatric Disorders

      • Amalie C. M. Couch, Anthony C. Vernon
      Pages 133-157
    10. The Human Leukocyte Antigen System in Psychiatry: Where Do We Stand?

      • Ryad Tamouza, Rajagopal Krishnamoorthy, Marion Leboyer
      Pages 169-181
    11. Testable Hypotheses Relating Complement Pathways to Elevated Risk for Schizophrenia

      • Lora McClain, Matthew Demers, Wenxiao Zheng, Maribeth Wesesky, Joel Wood, Leonardo D’Aiuto et al.
      Pages 183-194
    12. Gut Microbiome in Patients with Schizophrenia and Bipolar Disorder

      • Mohamed Genedi, Jenny Borkent, Magda Iouannou, Isabelle Janmaat, Benno Haarman, Iris E. Sommer
      Pages 195-212
  3. Immune Dysfunctions and Psychiatric Disorders

    1. Front Matter

      Pages 213-213
    2. Is Autism Spectrum Disorder Related to Immune Dysfunction(s)?

      • Florian Lejuste, Ryad Tamouza, Marion Leboyer
      Pages 215-225
    3. Inflammation and Immunity in Schizophrenia

      • Norbert Müller
      Pages 227-240
    4. The Aberrant Immune System in Bipolar Disorder

      • Bartholomeus C. M. Haarman, Elissa L. Stam, Jenny Borkent, Magdalini Ioannou, Hemmo A. Drexhage
      Pages 241-257
    5. Inflammation and Depression: Is Immunometabolism the Missing Link?

      • Robert Dantzer, Angela Casaril, Elisabeth Vichaya
      Pages 259-287
    6. Immune Dysfunction in Obsessive-Compulsive Disorder: From Risk Factors to Multisystem Involvement

      • Ana Maia, Bernardo Barahona-Corrêa, Albino J. Oliveira-Maia, José Oliveira
      Pages 289-307

About this book

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression…) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.


  • Immunology
  • Inflammation
  • Microglia
  • Immune modulation therapies
  • Pathophysiology

Editors and Affiliations

  • Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia

    Michael Berk

  • University Paris Est Créteil (UPEC), Inserm, IMRB (Translational NeuroPsychiatry lab), AP-HP, DMU IMPACT, AP-HP, Fondation FondaMental, Créteil, France

    Marion Leboyer

  • UMC Groningen, Groningen, The Netherlands

    Iris E. Sommer

About the editors

Michael Berk is an NHMRC Senior Principal Research Fellow at Deakin University, where he heads the IMPACT institute. He is listed by Thompson Reuters as amongst the world’s most influential scientific minds (2015-2020) and was awarded the Brain & Behaviour (NARSAD) Colvin Award for Mood Disorders in 2015, the Victoria Prize for life sciences in 2019 and the International Society for Bipolar Disorders Bob Post award for mentorship in 2020. He is past president of the International Society for Bipolar Disorders and the Australasian Society for Bipolar and Depressive Disorders. His major interests are in the discovery and implementation of novel therapies.

Marion Leboyer M.D., Ph.D. is Professor of Psychiatry at the University of Paris Est Créteil (UPEC) in France. She is Head of the University-affiliated Department of Psychiatry and Addiction, DMU IMPACT (Hôpitaux Universitaires Mondor, Assistance-Publique-Hôpitaux de Paris) and runs the “Translational Neuro Psychiatry” laboratory which is part of the Mondor Institute for Biomedical Research (Inserm U955). Since 2007, she has been the Executive Director of the non profit foundation, “Fondation FondaMental”, created by the French Ministry of Research. She is President of the ECNP Immuno-psychiatry TWG. She is listed as a highly cited researcher in 2020.

Iris Sommer MD, PhD is a Professor of Psychiatry working at the Biomedical and Psychiatry Departments of the University Medical Center Groningen (UMCG) in the Netherlands. She is an expert in psychotic disorders and leads several trials aiming to improve treatment in this patient group. She is an associate editor of Lancet Psychiatry and Psychological Medicine, and a board member of ECNP and SIRS. She is a founding member of the International Consortium of Hallucination Research and initiated the Gordon Research Conference cycle on cognitive dysfunction in brain disorders together with Prof. Linda Lam from the Chinese University of Hong Kong. In 2021, she was elected member of the Royal Holland Academy of Science.

Bibliographic Information

  • Book Title: Immuno-Psychiatry

  • Book Subtitle: Facts and Prospects

  • Editors: Michael Berk, Marion Leboyer, Iris E. Sommer

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-71228-0

  • eBook ISBN: 978-3-030-71229-7

  • Edition Number: 1

  • Number of Pages: XI, 444

  • Number of Illustrations: 4 b/w illustrations, 18 illustrations in colour

  • Topics: Psychiatry

Buying options

USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-71229-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Hardcover Book
USD 179.99
Price excludes VAT (USA)