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Reactive Oxygen Species

Network Pharmacology and Therapeutic Applications

  • Book
  • © 2021


  • This book is a game changer for the field and many clinical areas such as cardiology and neurology
  • Suggests a new approach to reactive oxygen species (ROS) and opens a new chapter in redox medicine
  • Leading book and reference for many years to come

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 264)

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Table of contents (16 chapters)

  1. ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine

  2. Targeting Antioxidant Responses

  3. Inhibiting ROS Formation and Toxification

  4. Stimulating/Substituting ROS

  5. Repairing ROS Damage


About this book

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leadingreference for ROSopathies and their treatment by network pharmacology.  

Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via  



Editors and Affiliations

  • Department of Pharmacology and Personalised Medicine, Maastricht University, Maastricht, The Netherlands

    Harald H. H. W. Schmidt

  • Brighton and Sussex Medical School, Brighton, UK

    Pietro Ghezzi

  • Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain

    Antonio Cuadrado

About the editors


Bibliographic Information

  • Book Title: Reactive Oxygen Species

  • Book Subtitle: Network Pharmacology and Therapeutic Applications

  • Editors: Harald H. H. W. Schmidt, Pietro Ghezzi, Antonio Cuadrado

  • Series Title: Handbook of Experimental Pharmacology

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-68509-6Published: 24 February 2021

  • Softcover ISBN: 978-3-030-68512-6Published: 24 February 2022

  • eBook ISBN: 978-3-030-68510-2Published: 23 February 2021

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: VIII, 425

  • Number of Illustrations: 70 illustrations in colour

  • Topics: Pharmacology/Toxicology, Cardiology, Neurosciences, Medical Biochemistry

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