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Botulinum Toxin Therapy

  • Book
  • © 2021

Overview

Editors:
  1. Scott M. Whitcup

    1. Akrivista and Whitecap Biosciences, Irvine, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Mark Hallett

    1. Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Provides an up-to-date review of the basic science of botulinum toxins and their therapeutic applications
  • Discusses the clinical approach to using botulinum toxin therapy, and thoroughly reviews the major therapeutic applications of botulinum toxins
  • Reviews both the science and therapy of currently approved botulinum toxins and the development of novel botulinum toxins

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 263)

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About this book

In a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases. Part 1 of the book reviews the basic science of botulinum toxins including advances in our understanding of  the molecular structure and mechanism of action of botulinum toxins. This section also discusses the manufacturing and formulation of botulinum toxins for clinical use and the development of novel therapeutic toxins for the future. Part 2 reviews the use of botulinum toxins in clinical practice. It discusses the clinical pharmacology of botulinum toxin drugs and their use in a wide variety of clinical conditions including headache, spasticity, pain, disorders of the genitourinary and gastrointestinal tract, strabismus, and medical aesthetics.


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Table of contents (21 chapters)

  1. Front Matter

    Pages i-viii
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  2. Basic Sciences

    1. Front Matter

      Pages 1-1
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    2. The History of Botulinum Toxins in Medicine: A Thousand Year Journey

      • Scott M. Whitcup
      Pages 3-10

    3. The Structure and Classification of Botulinum Toxins

      • Min Dong, Pål Stenmark
      Pages 11-33

    4. Botulinum Neurotoxins: Mechanism of Action

      • O. Rossetto, M. Pirazzini, F. Fabris, C. Montecucco
      Pages 35-47

    5. Manufacturing and Clinical Formulations of Botulinum Neurotoxins

      • Fauad Hasan
      Pages 49-62

    6. Novel Native and Engineered Botulinum Neurotoxins

      • Lance Steward, Mitchell F. Brin, Amy Brideau-Andersen
      Pages 63-89

  3. Clinical Practice

    1. Front Matter

      Pages 91-91
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    2. Clinical Pharmacology of Botulinum Toxin Drugs

      • Dirk Dressler
      Pages 93-106

    3. The Use of Botulinum Toxin for Treatment of the Dystonias

      • Alfredo Berardelli, Antonella Conte
      Pages 107-126

    4. The Use of Botulinum Toxin for Treatment of Spasticity

      • Sheng Li, Gerard E. Francisco
      Pages 127-146

    5. Use of Botulinum Toxin in Ophthalmology

      • Michael J. Wan, Sara AlShaker, David G. Hunter
      Pages 147-160

    6. Hyperhidrosis and Aesthetics

      • Jordan V. Wang, Nazanin Saedi, Christopher B. Zachary
      Pages 161-170

    7. Use of Botulinum Toxin in the Genitourinary System

      • Michael B. Chancellor, Christopher P. Smith
      Pages 171-184

    8. Gastrointestinal Uses of Botulinum Toxin

      • Maria Cariati, Maria Michela Chiarello, Marco Cannistra’, Maria Antonietta Lerose, Giuseppe Brisinda
      Pages 185-226

    9. The Use of Botulinum Toxin in the Management of Headache Disorders

      • Hsiangkuo Yuan, Stephen D. Silberstein
      Pages 227-249

    10. Botulinum Toxin and Pain

      • Zdravko Lacković
      Pages 251-264

    11. The Use of Botulinum Toxin for Treatment of Depression

      • M. Axel Wollmer, Michelle Magid, Tillmann H. C. Kruger, Eric Finzi
      Pages 265-278

    12. Correction to: The Use of Botulinum Toxin for Treatment of Depression

      • M. Axel Wollmer, Michelle Magid, Tillmann H. C. Kruger, Eric Finzi
      Pages 279-279

    13. Correction to: The Use of Botulinum Toxin for Treatment of Spasticity

      • Sheng Li, Gerard E. Francisco
      Pages 281-281
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Editors and Affiliations

  • Akrivista and Whitecap Biosciences, Irvine, USA

    Scott M. Whitcup

  • Bethesda, USA

    Mark Hallett

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