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  • © 2021

Experimental Design and Reproducibility in Preclinical Animal Studies

  • Comprehensive guide on how to design and conduct reproducible animal studies

  • Introduction to statistical methods essential for performing animal studies

  • Discusses in detail how factors like genetic background can influence an experiment’s outcome

Part of the book series: Laboratory Animal Science and Medicine (LASM, volume 1)

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eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-66147-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
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  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vi
  2. The Animal and Its Environment

    1. Front Matter

      Pages 1-1
    2. An Introduction to Reproducibility in the Context of Animal Research

      • José M. Sánchez-Morgado, Aurora Brønstad
      Pages 3-10
    3. Rodent Genetics

      • Fernando Benavides, Jean-Louis Guénet
      Pages 11-52
    4. Animal and Environmental Factors That Influence Reproducibility

      • José M. Sánchez-Morgado, Aurora Brønstad, Kathleen Pritchett-Corning
      Pages 53-75
    5. Microbiology and Microbiome

      • Axel Kornerup Hansen
      Pages 77-104
  3. Statistics: Basics and Explanation of Different Designs and Tests

    1. Front Matter

      Pages 127-127
    2. Why Do We Need a Statistical Experiment Design?

      • Michael Parkinson, Carlos Oscar Sánchez Sorzano
      Pages 129-146
    3. Statistical Tests and Sample Size Calculations

      • Michael Parkinson, Carlos Oscar Sánchez Sorzano
      Pages 147-164
    4. Design of Experiments

      • Michael Parkinson, Carlos Oscar Sánchez Sorzano
      Pages 165-181
  4. Systematic Reviews and Publishing

    1. Front Matter

      Pages 183-183
    2. Scholarly Publishing and Scientific Reproducibility

      • Arieh Bomzon, Graham Tobin
      Pages 185-211
    3. Systematic Reviews

      • Janet Becker Rodgers, Merel Ritskes-Hoitinga
      Pages 213-261
    4. Planning Animal Experiments

      • Adrian J. Smith
      Pages 263-277

About this book

This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. 
 
The book addresses advanced undergraduates, graduate students and all scientists working with animals.

Keywords

  • experimental design
  • laboratory animals
  • veterinary genetics
  • registration of animal experiments
  • preclinical studies

Editors and Affiliations

  • Comparative Medicine, Trinity College Dublin Comparative Medicine, Dublin, Ireland

    José M. Sánchez Morgado

  • University of Bergen, Laboratory Animal Science University of Bergen, Bergen, Norway

    Aurora Brønstad

About the editors

José M. Sánchez Morgado, DVM, MSc, PhD, Dip. ECLAM qualified as veterinarian at the Universidad Complutense of Madrid. He is European Veterinary Specialist in Laboratory Animal Medicine and Veterinary Council Ireland recognised Specialist in Laboratory Animal Medicine. Dr. Sánchez Morgado is currently Director of Comparative Medicine and Adjunct Associate Professor at Trinity College Dublin. He is also one of the Editors in Chief of the Laboratory Animals journal. Dr. Sánchez Morgado described a case of non-human primate intersex in 2003. Furthermore, he published studies on virulence of canine coronaviruses, Mycobacterium gordonae infection of amphibians, and on diagnostic discrepancies of Helicobacter spp., a common rodent pathogen, by different laboratories, and a new helicobacter diagnostic assay. He has worked as Designated Veterinarian in the UK, Spain and the Republic of Ireland, and has managed two laboratory animal care and user programs.

Aurora Brønstad, DVM, PhD, has been the chief veterinarian and head of the animal facility at University of Bergen (UiB), Norway, since 1999 where she also is responsible for the training in Laboratory Animal Science. She has been involved in several national and international committees, boards and network including the board of the Scand-LAS (2002-2008). She was member of the National Animal Research Authority (2003-2009), Norwegian delegate in Management Committee COST B24: Laboratory animal science and welfare (2004-2009), Nordic infrastructure for Mouse Models (IMM) WG4: Harmonization of procedures in animals handling and welfare (2008-2016), Board member of ILAB since 2009. Co-Chair of AALAS - FELASA working group on harm-benefit analysis of animal studies (2012-2016). Dr. Brønstad is member of the European Society of Laboratory Animal Veterinarians (ESLAV) since 2009 and served as the society’s President between 2017-2019. Further, she was appointed as an Ad hoc Consultant for the international Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) (2011-2016) and has also served in the AAALAC Council board since 2016. In 2016 she received the Charles River Award for the work in the American Association for Laboratory Animal Science (AALAS) - Federation of European Laboratory Animal Science Associations (FELASA) working group on harm-benefit analysis of animal studies, providing guidelines to advance the public’s understanding why animal models are used in research. 


Bibliographic Information

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-66147-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)