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  • © 2021

Ferroptosis: Mechanism and Diseases

Editors:

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  • Provides a unique perspective on practical aspects of ferroptosis, with in-depth coverage of pathologies from Cancer to COVID-19

  • Gives a comprehensive and up-to-date guide of small molecules modulating ferroptosis and their potential mechanism of action

  • Discusses other non-apoptotic forms of cell death and the role of ferritinophagy in ferroptosis

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1301)

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  • ISBN: 978-3-030-62026-4
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Table of contents (7 chapters)

  1. Front Matter

    Pages i-ix
  2. Ferroptosis: Concepts and Definitions

    • Andrés F. Flórez, Hamed Alborzinia
    Pages 1-5
  3. Overcoming Therapeutic Challenges for Pancreatic Ductal AdenocarcinomaPancreatic ductal adenocarcinoma (PDAC) with xCT Inhibitors

    • Milica Vucetic, Boutaina Daher, Shamir Cassim, Scott Parks, Jacques Pouyssegur
    Pages 7-24
  4. The Role of NCOA4-Mediated FerritinophagyFerritinophagy in FerroptosisFerroptosis

    • Naiara Santana-Codina, Ajami Gikandi, Joseph D. Mancias
    Pages 41-57
  5. Emerging Role for FerroptosisFerroptosis in Infectious DiseasesInfectious diseases

    • Eduardo Pinheiro Amaral, Sivaranjani Namasivayam
    Pages 59-79
  6. Small MoleculeSmall molecules Regulators of FerroptosisFerroptosis

    • Sylvain Debieu, Stéphanie Solier, Ludovic Colombeau, Antoine Versini, Fabien Sindikubwabo, Alison Forrester et al.
    Pages 81-121
  7. NecroptosisNecroptosis, the Other Main Caspase-Independent Cell DeathCell death

    • Larissa C. Zanetti, Ricardo Weinlich
    Pages 123-138
  8. Back Matter

    Pages 139-140

About this book

This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis.

While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.

Keywords

  • ferroptosis
  • lipid peroxidation
  • ROS
  • cancer
  • GPX4

Editors and Affiliations

  • Department of Molecular and Cellular Biology, Harvard University, Cambridge, USA

    Andrés F. Florez

  • Division of Stem Cells and Cancer German Cancer Research Center (DKFZ) and Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany

    Hamed Alborzinia

About the editors

Dr. Andrés F. Flórez is currently a Postdoctoral Fellow in the Department of Molecular and Cellular Biology (MCB) at Harvard University. His research is focused in understanding the oncogene-based mechanisms regulating ferroptosis and to use this knowledge for designing new therapeutic strategies. He is also interested in the role of ferroptosis in controlling bacterial cell populations.

Dr. Hamed Alborzinia is a Postdoctoral Fellow in the Division of Stem Cells and Cancer at the German Cancer Research Center (DKFZ). He also belongs to the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in Heidelberg, Germany. His main research focus is to understand the metabolic properties of cancer cells in connection to novel forms of cell death, including ferroptosis.

 

Bibliographic Information

Buying options

eBook
USD 119.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-62026-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Hardcover Book
USD 159.99
Price excludes VAT (USA)