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Studies on Biomarkers and New Targets in Aging Research in Iran

Focus on Turmeric and Curcumin

Editors:

  • Emphasizes the emerging role of the Middle East in the area of age-related diseases

  • Describes the identification of biomarkers and new drug targets in age-related diseases

  • Emphasizes the potential values of natural products such as turmeric and curcumin in diverse medical fields

  • Details studies and research underway on age-related disorders and diseases in the Middle East and worldwide

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1291)

Part of the book sub series: Proteomics, Metabolomics, Interactomics and Systems Biology (PMISB)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-ix
  2. Research in the Middle East into the Health Benefits of Curcumin

    • Paul C. Guest, Amirhosein Sahebkar
    Pages 1-13
  3. Turmeric and Curcumin: From Traditional to Modern Medicine

    • Maryam Akaberi, Amirhossein Sahebkar, Seyed Ahmad Emami
    Pages 15-39
  4. Targeting Nuclear Factor-Kappa B Signaling Pathway by Curcumin: Implications for the Treatment of Multiple Sclerosis

    • Meysam Gachpazan, Sadra Habbibirad, Hoda Kashani, Tannaz Jamialahmadi, Hamid Reza Rahimi, Amirhossein Sahebkar
    Pages 41-53
  5. Carbon-based Nanomaterials and Curcumin: A Review of Biosensing Applications

    • Mohammad Mohajeri, Behzad Behnam, Aida Tasbandi, Tannaz Jamialahmadi, Amirhossein Sahebkar
    Pages 55-74
  6. Effects of Curcumin and Its Analogues on Infectious Diseases

    • Reza Ranjbar, Hossein Bagheri, Faezeh Ghasemi, Paul C. Guest, Amirhossein Sahebkar
    Pages 75-101
  7. Protective Effects of Curcumin on Endothelium: An Updated Review

    • Mona Alidadi, Luca Liberale, Fabrizio Montecucco, Muhammed Majeed, Khalid Al-Rasadi, Maciej Banach et al.
    Pages 103-119
  8. The Effect of Curcumin Supplemsentation on Anthropometric Indices in Overweight and Obese Individuals: A Systematic Review of Randomized Controlled Trials

    • Zahra Safari, Mohammad Bagherniya, Gholamreza Askari, Thozhukat Sathyapalan, Amirhossein Sahebkar
    Pages 121-137
  9. Effect of Curcumin on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review of Randomized Clinical Trials

    • Atena Mahdavi, Sajjad Moradi, Gholamreza Askari, Bijan Iraj, Thozhukat Sathyapalan, Paul C. Guest et al.
    Pages 139-149
  10. Antidiabetic Properties of Curcumin: Insights on New Mechanisms

    • Elahe Mohammadi, Behzad Behnam, Reza Mohammadinejad, Paul C. Guest, Luis E. Simental-Mendía, Amirhossein Sahebkar
    Pages 151-164
  11. The Effect of Curcumin in Improving Lipid Profile in Patients with Cardiovascular Risk Factors: A Systematic Review of Clinical Trials

    • Sahar Rafiee, Mohammad Bagherniya, Gholamreza Askari, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar
    Pages 165-177
  12. The Effects of Curcumin in the Treatment of Gingivitis: A Systematic Review of Clinical Trials

    • Farinaz Shirban, Fateme Gharibpour, Ailin Ehteshami, Mohammad Bagherniya, Thozhukat Sathyapalan, Amirhossein Sahebkar
    Pages 179-211
  13. Does Curcumin Have an Anticaries Effect? A Systematic Review of In Vitro Studies

    • Ailin Ehteshami, Farinaz Shirban, Fateme Gharibpour, Mohammad Bagherniya, Thozhukat Sathyapalan, Amirhossein Sahebkar
    Pages 213-227
  14. The Clinical Use of Curcumin for the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Clinical Trials

    • Fateme Gharibpour, Omid Fakheran, Alireza Parvaneh, Farinaz Shirban, Mohammad Bagherniya, Thozhukat Sathyapalan et al.
    Pages 229-238
  15. Antibacterial Activity of Curcumin Against Periodontal Pathogens: A Systematic Review

    • Omid Fakheran, Abbasali Khademi, Mohammad Bagherniya, Mandana Dehghannejad, Thozhukat Sathyapalan, Amirhossein Sahebkar
    Pages 239-249
  16. The Clinical Use of Curcumin for the Treatment of Rheumatoid Arthritis: A Systematic Review of Clinical Trials

    • Mohammad Bagherniya, Mina Darand, Gholamreza Askari, Paul C. Guest, Thozhukat Sathyapalan, Amirhossein Sahebkar
    Pages 251-263
  17. A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis

    • Nafiseh Shokri-Mashhadi, Mohammad Bagherniya, Gholamreza Askari, Thozhukat Sathyapalan, Amirhossein Sahebkar
    Pages 265-282
  18. Effects of Curcumin on Depression and Anxiety: A Narrative Review of the Recent Clinical Data

    • Mohammad Amin Khodadadegan, Shakiba Azami, Paul C. Guest, Tannaz Jamialahmadi, Amirhossein Sahebkar
    Pages 283-294
  19. A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases

    • Masoumeh Atefi, Mina Darand, Mohammad Hassan Entezari, Tannaz Jamialahmadi, Mohammad Bagherniya, Amirhossein Sahebkar
    Pages 295-326
  20. The Use of Curcumin for the Treatment of Renal Disorders: A Systematic Review of Randomized Controlled Trials

    • Mohammad Bagherniya, Davood Soleimani, Mohammad Hossein Rouhani, Gholamreza Askari, Thozhukat Sathyapalan, Amirhossein Sahebkar
    Pages 327-343

About this book

The Middle East is known as the cradle of civilization. It was the crossroads of ancient empires and the birthplace of major world religions. Today it is the center of many world issues due to its economic, religious and political importance. Although it has lagged behind many other regions of the world in medicinal research, this has increased dramatically in recent years with increasing numbers of relevant publications and the country of Iran has spearheaded this progress. Much of the research has focused on increasing our understanding of the aging process and attempting to identify biomarkers and natural products to improve the human healthspan. This book provides a comprehensive overview of the research conducted in the Middle East on the health benefits of curcumin, a phytochemical derived from the famous spice turmeric. Hundreds of studies have now been published describing the health benefits of this spice. The importance of this research is exemplified by poor data regarding health and longevity as only 0.08% of the population in Iran consists of individuals over 90 years of age. This is approximately 10 times lower than the percentage of this same age group in the United Kingdom and the United States of America and almost 20 times lower than that in Japan.     


This book presents a series of reviews and meta-studies describing research which has resulted in identification potential new biomarkers and drug targets for age-related disorders. All of the studies have focussed on the testing of curcumin and related products, which have already shown some promising leads in age-related conditions such as heart-disease, diabetes, cognitive impairment and cancer. The authors in this series come from different centers and cities of Iran, including Mashhad, Tehran, Isfahan, Ahvaz, Birjand, Quchan and Yazd, and many of the chapters feature collaborations with other countries of the Middle East and throughout the world, including Brazil, Italy, Mexico, Oman, Poland, Switzerland, the United Kingdom and the United States of America. This underscores the emergence of the Middle East into this arena of research.  


The book will be of high interest to scientific and clinical researchers in the subject of aging and age-related disease, and to physicians and pharmaceutical company scientists since it gives insights into the latest strategies, biomarkers and targets involved in the mechanism of action of curcumin to promote healthy aging. It will also provide important information on disease mechanisms related to age-related disorders, as each chapter will be presented in the context of specific chronic diseases. 

Editors and Affiliations

  • University of Campinas, Sao Paulo, Brazil

    Paul C. Guest

About the editor

Dr. Paul C. Guest, Ph.D, is a scientific researcher/writer with 37years of experience in the fields of metabolic and neurological disorders. This includes experience in both academia and the pharmaceutical industry with the majority of time spent at the University of Cambridge and Merck Sharp & Dohme in the United Kingdom. He has also been affiliated with the University of Campinas in Sao Paulo Brazil since 2015, still focused on advancing the field of biomarkers for neurological disorders such as schizophrenia and Alzheimer’s disease, and more recently in the area of anti-aging research.

Bibliographic Information

  • Book Title: Studies on Biomarkers and New Targets in Aging Research in Iran

  • Book Subtitle: Focus on Turmeric and Curcumin

  • Editors: Paul C. Guest

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-030-56153-6

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-56152-9Published: 01 August 2021

  • eBook ISBN: 978-3-030-56153-6Published: 31 July 2021

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: IX, 381

  • Number of Illustrations: 37 b/w illustrations, 37 illustrations in colour

  • Topics: Bioinformatics, Biomedicine, general, Aging

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access