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  • © 2020

Saliva in Health and Disease

The Present and Future of a Unique Sample for Diagnosis

  • Highlights saliva as a substitute for blood in the management of local and systemic pathologies

  • Discusses the precautions and confounding factors, which should be taken in account when using saliva

  • Contains and discusses data humans studies and animal models

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eBook USD 129.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-37681-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 169.99
Price excludes VAT (USA)
Hardcover Book USD 169.99
Price excludes VAT (USA)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-x
  2. Saliva Basics

    1. Front Matter

      Pages 1-1
    2. Salivary Glands’ Anatomy and Physiology

      • María D. Contreras-Aguilar, Francisco Gómez-García
      Pages 3-21
    3. Saliva in Ingestive Behavior Research: Association with Oral Sensory Perception and Food Intake

      • Elsa Lamy, Ann-Marie Torregrossa, Paula Midori Castelo, Fernando Capela e Silva
      Pages 23-48
    4. Saliva as a Non-invasive Sample: Pros and Cons

      • Lorena Franco-Martínez, Candela Castillo-Felipe
      Pages 49-65
    5. Methodology Assays for the Salivary Biomarkers’ Identification and Measurement

      • Lorena Franco-Martínez, Camila Peres Rubio, María D. Contreras-Aguilar
      Pages 67-95
  3. Salivary Biomarkers in Oral and Systemic Pathologies

    1. Front Matter

      Pages 97-97
    2. The Role of Saliva in Dental Practice

      • Eduardo Pons-Fuster, Pia López-Jornet
      Pages 99-109
    3. Salivary Biomarkers in Respiratory Diseases

      • Jovita Mazeikiene
      Pages 111-120
    4. Salivary Biomarkers in Neurologic Diseases

      • Zeineb Zian, Assia Bouhoudan
      Pages 121-152
    5. Salivary Biomarkers in the Diagnosis and Monitoring of Metabolic and Endocrine Diseases

      • Asta Tvarijonaviciute, Sónia Lucena, Fernando Capela e Silva, Elsa Lamy
      Pages 153-176
    6. Salivary Markers in Inflammatory and Autoimmune Diseases

      • Alberto Muñoz-Prieto, Eduardo Pons-Fuster, Pia López-Jornet
      Pages 177-192
    7. Salivary Biomarkers in Kidney Diseases

      • Mateusz Maciejczyk, Piotr Żukowski, Anna Zalewska
      Pages 193-219
    8. Salivary Diagnosis of Infectious Diseases

      • Silvia Martínez-Subiela, Ana Cantos-Barreda
      Pages 221-245
    9. Salivary Markers in Systemic and Oral Cancer

      • Mario Pérez-Sayáns, Cintia M. Chamorro-Petronacci, Pilar Gándara-Vila, Alejandro I. Lorenzo-Pouso
      Pages 247-280
    10. Saliva in Sport Sciences

      • Jose J. Cerón
      Pages 281-292
    11. Salivary Biomarkers in Welfare Studies

      • Damián Escribano, Fernando Tecles
      Pages 293-319
    12. The Future of Saliva as an Analytical Sample

      • Asta Tvarijonaviciute, Silvia Martínez-Subiela, Pia López-Jornet, Elsa Lamy
      Pages 321-326

About this book

Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff.

In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.


Keywords

  • Diagnostics
  • Biomarkers
  • Oral Pathologies
  • Systemic Pathologies
  • Human Samples
  • Animal Models

Editors and Affiliations

  • Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, Spain

    Asta Tvarijonaviciute

  • Interlab-UMU, University of Murcia, Murcia, Spain

    Silvia Martínez-Subiela

  • Department of Oral Medicine, Faculty of Medicine and Dentistry, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, Spain

    Pia López-Jornet

  • MED - Mediterranean Institute for Agriculture Environment and Development, IIFA - Instituto de Investigação e Formação Avançada, University of Évora, Évora, Portugal

    Elsa Lamy

About the editors

Asta Tvarijonaviciute received her degree in Veterinary cum Laude from University of Kaunas, Lituania in 2006 and her Ph.D. in Veterinary Sciences in 2012 at the University of Murcia, Spain. She is currently post-doctoral researcher granted by Spanish Ministry of Science under the program “Ramon y Cajal” at the Interdiciplinary Laboratory of University of Murcia (Interlab-UMU). Her research activity is focused mainly on the study of biomarkers of health and welfare, which comprises the analytes that are used for monitoring the health status and the level of stress in different species and tissues by non-invasive ways and is documented by more than 130 publications on peer-reviewed international scientific journals, 3 book chapters and several communications in international and national congresses.

Silvia Martinez-Subiela received her degree in Veterinary Medicine from University of Murcia in 1999 and her Ph.D. in Veterinary Medicine in 2003. She is currently Associate Professor at the Medicine and Surgery Department of the University of Murcia and member for the Service of Veterinary Diagnostic Laboratory of Murcia University (accredited by European Society of Veterinary Clinical Pathology). During her studies she was awarded several scholarships for excellence: University of Murcia and National Excellence Awards for the best academic qualifications in Veterinary degree studies, University of Murcia Excellence Award for the best PhD thesis in Veterinary studies and The Veterinary Journal 2003 Junior scientist literary Prize. She has 18 years of experience in the development and validation of assays for biomarker quantification in serum and other fluids such as saliva, mainly in the field of acute phase proteins, obesity and stress. She has over 130 publications in high impact journals of this field with an H-index of 34 and has participated in 12 research projects. She is a member of the editorial boards of 2 veterinary journals and a regular reviewer of several journals.

Pia Lopez Jornet has a degree in Medicine, specialized in Stomatology, at the University of Valencia, Spain. She obtained her Ph.D. in 1992 at the University of Murcia, Spain. She is Professor, Consultant and responsible for the Oral disease School of Medicine and Dentistry at the University of Murcia.  She has been Director of the Stomatology Department (University of Murcia) and a Council member of the Spanish Society of Oral Medicine. She has written more than 200 peer-reviewed papers and co-authored several books. She has participated in more than 200 congresses, presenting main, oral and poster communications. She has been invited to give about 30 Plenary Lectures at International Symposia and at several Universities.

Elsa Lamy received his PhD in Agriculturl Sciences (Zootechnics) from the University of Évora in 2009 and her Master degree in Metabolic diseases and ingestive behaviour from the University of Lisbon, in 2014. She was invited adjunt Professor from 2010 to 2012 in the area of Food Sciences, in the Higher School of Turism and Hospitality of Estoril. After working as Posdoc grant holder (2010-2014), she is Assistant Researcher at the University of Evora, also teaching Ingestive Behavior Physiology in that university. Elsa Lamy has published more than 30 publications in international journals and contributed about 10 chapters to International Books. She participates in Editorial Board of one international peer reviewed journal and has participated in the edition of Special Issues for other international journals. Her main field of interest is in the area of salivary proteomics, more precisely in the understanding about the relationship between saliva protein composition and oral food perception and consequent food preferences and choices.

Bibliographic Information

  • Book Title: Saliva in Health and Disease

  • Book Subtitle: The Present and Future of a Unique Sample for Diagnosis

  • Editors: Asta Tvarijonaviciute, Silvia Martínez-Subiela, Pia López-Jornet, Elsa Lamy

  • DOI: https://doi.org/10.1007/978-3-030-37681-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-37680-2

  • Softcover ISBN: 978-3-030-37683-3

  • eBook ISBN: 978-3-030-37681-9

  • Edition Number: 1

  • Number of Pages: X, 326

  • Number of Illustrations: 4 b/w illustrations, 19 illustrations in colour

  • Topics: Human Physiology, Biomedical Research, Pathology, Animal Physiology

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-37681-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 169.99
Price excludes VAT (USA)
Hardcover Book USD 169.99
Price excludes VAT (USA)