Skip to main content

Tumor Microenvironment

The Main Driver of Metabolic Adaptation

  • Book
  • © 2020


  • An integrative view of tumor microenvironment and cancer metabolic adaptations, focusing different cancer contexts and interspecific cellular actions
  • A wide range of traits, showing the way cancer adapts metabolically to the microenvironment
  • A clear presentation of different cancer models and analytical techniques, their usefulness, advantages and limitations

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1219)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

eBook USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

About this book

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics.

In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. Themetabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book.

The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

Similar content being viewed by others


Table of contents (24 chapters)

  1. Adaptive Metabolic Features Are Sustained by Tumor Microenvironment

  2. Microenvironment and Metabolic Signalling: The Way Cancer Cells Know How to Survive

  3. Metabolic Fitness and Therapy Response in Cancer

Editors and Affiliations

  • CEDOC, Chronic Diseases Research Centre, NOVA Medical School | Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal

    Jacinta Serpa

About the editor

Jacinta Serpa is an Assistant Professor and Senior Researcher at the Universidade Nova de Lisboa. 

Bibliographic Information

Publish with us