Microbial Cyclic Di-Nucleotide Signaling

  • Shan-Ho Chou
  • Nicolas Guiliani
  • Vincent T. Lee
  • Ute Römling

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Biochemistry/Structural Biology—Enzymes

    1. Front Matter
      Pages 1-1
    2. Anushya Petchiappan, Avisek Mahapa, Dipankar Chatterji
      Pages 3-25
    3. Dom Bellini, Andrew Hutchin, Odel Soren, Jeremy S. Webb, Ivo Tews, Martin A. Walsh
      Pages 27-48
    4. Serena Rinaldo, Alessandro Paiardini, Alessio Paone, Francesca Cutruzzolà, Giorgio Giardina
      Pages 65-78
  3. Biochemistry/Structural Biology—Receptors

    1. Front Matter
      Pages 105-105
    2. Shan-Ho Chou, Michael Y. Galperin
      Pages 125-134
  4. Biochemistry/Structural Biology—Sensing

    1. Front Matter
      Pages 135-135
    2. Hannah Dayton, Marina K. Smiley, Farhad Forouhar, Joe J. Harrison, Alexa Price-Whelan, Lars E. P. Dietrich
      Pages 137-158
  5. Cyclic di-AMP: Biochemistry and Physiology

    1. Front Matter
      Pages 159-159
    2. Liang Tong, Joshua J. Woodward
      Pages 161-175
    3. Mark S. Turner, Thu Ngoc Minh Vu, Esteban Marcellin, Zhao-Xun Liang, Huong Thi Pham
      Pages 177-189
  6. Population Diversity

    1. Front Matter
      Pages 191-191
  7. Cyclic di-GMP and Exopolysaccharide Regulation

    1. Front Matter
      Pages 209-209
    2. M. Fata Moradali, Bernd H. A. Rehm
      Pages 223-238
  8. Environmental Bacteria

    1. Front Matter
      Pages 239-239
    2. Cordelia A. Weiss, Wade C. Winkler
      Pages 241-260
    3. Wen Yin, Lu Liu, Siyang Xu, Jin He
      Pages 261-275
    4. Sarah M. Yannarell, Loni Townsley, Elizabeth A. Shank
      Pages 277-291
    5. María Pérez-Burgos, Lotte Søgaard-Andersen
      Pages 293-309
    6. Gen Enomoto, Annegret Wilde, Masahiko Ikeuchi
      Pages 311-327
    7. Guoliang Qian, Gaoge Xu, Shan-Ho Chou, Mark Gomelsky, Fengquan Liu
      Pages 329-336
    8. Matías Castro, Mauricio Díaz, Ana Moya Beltrán, Nicolas Guiliani
      Pages 337-353
  9. Pathogens

    1. Front Matter
      Pages 355-355
    2. Erin Young, Garett Bonds, Ece Karatan
      Pages 357-378
    3. Meng-Lun Hsieh, Deborah M. Hinton, Christopher M. Waters
      Pages 379-394
    4. Yinlan Bai, Guangchun Bai
      Pages 443-454
    5. Tiffany M. Zarrella, Guangchun Bai
      Pages 455-468
  10. Gram-Negative Bacteria

    1. Front Matter
      Pages 469-469
    2. Matthew J. Pestrak, Daniel J. Wozniak
      Pages 471-486
    3. Nikola Zlatkov, Bernt Eric Uhlin
      Pages 487-517
    4. Grace I. Borlee, Mihnea R. Mangalea, Bradley R. Borlee
      Pages 519-543
  11. Cyclic di-GMP Signaling in Eukaryotes

    1. Front Matter
      Pages 561-561
  12. Interference Strategies

    1. Front Matter
      Pages 575-575
    2. Herman O. Sintim, Clement Opoku-Temeng
      Pages 577-591
  13. Novel Cyclic Di-Nucleotides

    1. Front Matter
      Pages 593-593
    2. Todd A. Wright, Andrew B. Dippel, Ming C. Hammond
      Pages 595-611
    3. Miriam S. Ramliden, Geoffrey B. Severin, Brendan J. O’Hara, Christopher M. Waters, Wai-Leung Ng
      Pages 613-623
  14. Honorary Cyclic Nucleotides

    1. Front Matter
      Pages 625-625
    2. Benjamin M. Fontaine, Yashasvika Duggal, Emily E. Weinert
      Pages 627-637

About this book


This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described.

In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior.

Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.


Microbiology second messengers cyclic di-GMP cyclic GAMP cyclic di-AMP 2’3 cyclic AMP biofilm formation motility virulence receptors bacterial signaling

Editors and affiliations

  • Shan-Ho Chou
    • 1
  • Nicolas Guiliani
    • 2
  • Vincent T. Lee
    • 3
  • Ute Römling
    • 4
  1. 1.Institute of Biochemistry and Agricultural Biotechnology CenterNational Chung Hsing UniversityTaichungTaiwan
  2. 2.Department of Biology, Faculty of SciencesUniversidad de ChileSantiagoChile
  3. 3.Department of Cell Biology and Molecular GeneticsUniversity of MarylandCollege ParkUSA
  4. 4.Department of Microbiology, Tumor and Cell BiologyKarolinska InstitutetStockholmSweden

Bibliographic information