Overview
- Provides an overview of recent developments in spirocyclization techniques adapted to carbohydrates
- Presents recent advances in the utility of sugar derived spiro-heterocycles
- Multi-authored volume with contributions from experts in the field
Part of the book series: Topics in Heterocyclic Chemistry (TOPICS, volume 57)
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About this book
This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. Especially their conjugates with practically all kinds of primary and secondary metabolic small molecules (and also biomacromolecules) representing valuable tools for glycobiology research and also lead compounds for drug discovery. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro(hetero)cyclic derivatives, in many cases of high therapeutical relevance. As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and (glyco)biologists, as well as researchers involved in various biomedical fields.
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Keywords
Table of contents (8 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
About the editor
László Somsák is a full Professor and Head of the Department of Organic Chemistry at the University of Debrecen, Hungary. He serves as an editorial board member for Carbohydrate Research, and as guest editor for special issues of Carbohydrate Research, Mini-Reviews in Medicinal Chemistry, Molecules. His research interests include synthetic carbohydrate chemistry directed to C-glycosyl compounds, anomeric-spirocycles, glycals, exo-glycals and their derivatives; development of synthetic methodology involving radicals and carbenes; synthesis of glycosidase and glycogen phosphorylase inhibitors as potential antidiabetics, study of their structure-activity relationships; synthesis of glycomimetics and glycopeptidomimetics.
Bibliographic Information
Book Title: Carbohydrate-spiro-heterocycles
Editors: László Somsák
Series Title: Topics in Heterocyclic Chemistry
DOI: https://doi.org/10.1007/978-3-030-31942-7
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-31941-0Published: 06 November 2019
Softcover ISBN: 978-3-030-31944-1Published: 06 November 2020
eBook ISBN: 978-3-030-31942-7Published: 26 October 2019
Series ISSN: 1861-9282
Series E-ISSN: 1861-9290
Edition Number: 1
Number of Pages: VII, 295
Number of Illustrations: 1 b/w illustrations
Topics: Organic Chemistry, Medicinal Chemistry, Biochemistry, general, Biomedical Engineering/Biotechnology, Industrial Chemistry/Chemical Engineering