Overview
- Unique in that this is the first book focused on one aspect of intracellular delivery that focuses on cancer and infectious diseases
- Essential advanced reference on receptor and receptor-mediated drug delivery
- Provides research that demonstrates high efficacy and decreased toxicity
- Serves as critical research for drug discovery in treating cancer and infectious diseases
- Each chapter includes a brief overview of the receptor and its occurence, alterations in receptor expression, recognition domain, binding of substrates to ligands, Structure activity relationship of substrate/ligand for selective binding, antagonist of ligand binding, natural and synthetic ligands, ligands in clinical development and clinical studies, targeted drug delivery strategies and conclusions and references
Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series (AAPS, volume 39)
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Table of contents (18 chapters)
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Receptor Mediated Endocytosis in Cancer and Infectious Diseases
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Models for Evaluation of Targeted Delivery in Cancer and Infectious Diseases
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Cellular Assays
Keywords
About this book
Editors and Affiliations
About the editors
Prajakta Dandekar received her PhD from the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai. Her doctoral research involved the development of polymeric nanoparticles for natural therapeutic agents. Later, she joined the Department of Macromolecular Organic Chemistry, University of Saarland, Saarbrucken, as a post-doctoral researcher and was involved in formulating nanoparticles of new hydrophobic starch polymers for encapsulating hydrophobic anti-cancer actives. She was the first woman scientist from India to be awarded the European Respiratory Society-Marie Curie Joint Postdoctoral Fellowship (long-term) and conducted the associated research involving formulation of nanoparticles for intracellular siRNA delivery at the Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrucken, Germany. From January 2012 until October 2014, she worked as Dr. John Kapoor Assistant Professorin Pharmaceutical Technology at the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai. Currently, she is UGC Assistant Professor in Engineering Sciences, in the same department. Her research interests involve design of siRNA-polymer nanocarriers, development of in vitro 2D and 3D cellular models, and developing biopolymer-scaffolds and microfluidic devices for tissue engineering.
Anisha A. D’Souza is currently working as Research Formulation Scientist at Piramal Enterprises Limited, Mumbai. She received her PhD (Tech.) in Pharmaceutics from the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai (ICT, Formerly known as UDCT). She was the recipient of the most coveted and prestigious ‘Prof. M. M. Sharma Doctoral Fellowship’ at ICT. Subsequently, during her post-doctoral tenure at IIT-Bombay, she has worked on delivery of micronutrients encapsulated nanoparticles incorporated in different cosmetics for improving mother and child health. Her research interest encompasses colloidal drug delivery systems viz., polymeric and solid lipid nanoparticles for enhanced bioavailability, controlled delivery and targeting. She has published research papers and reviews in peer reviewed journals and has coauthored number of book chapters.
Bibliographic Information
Book Title: Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis
Editors: Padma V. Devarajan, Prajakta Dandekar, Anisha A. D'Souza
Series Title: AAPS Advances in the Pharmaceutical Sciences Series
DOI: https://doi.org/10.1007/978-3-030-29168-6
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: American Association of Pharmaceutical Scientists 2019
Hardcover ISBN: 978-3-030-29167-9Published: 21 November 2019
eBook ISBN: 978-3-030-29168-6Published: 09 November 2019
Series ISSN: 2210-7371
Series E-ISSN: 2210-738X
Edition Number: 1
Number of Pages: XVIII, 560
Number of Illustrations: 37 b/w illustrations, 45 illustrations in colour
Topics: Pharmaceutical Sciences/Technology, Pharmacy, Cancer Research, Infectious Diseases