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Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis

  • Padma V. Devarajan
  • Prajakta Dandekar
  • Anisha A. D'Souza
Book

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 39)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Introduction and Overview

    1. Front Matter
      Pages 1-1
    2. Dhanashree H. Surve, Prajakta Dandekar, Padma V. Devarajan, Anil B. Jindal
      Pages 3-41
  3. Receptors and Receptor Mediated Endocytosis in Cancer

    1. Front Matter
      Pages 43-43
    2. Rijo John, Heero Vaswani, Prajakta Dandekar, Padma V. Devarajan
      Pages 45-78
    3. Ashish Pandit, Lalit Khare, Padma V. Devarajan, Ratnesh Jain, Prajakta Dandekar
      Pages 79-108
    4. Manish Gore, Amita Puranik, Abhishek Indurkar, Bismita Sonowal, Padma V. Devarajan, Ratnesh Jain et al.
      Pages 109-140
    5. Tejal Pant, Nikita Aware, Padma V. Devarajan, Ratnesh Jain, Prajakta Dandekar
      Pages 141-170
    6. Aditya Narvekar, Ashu Srivastav, Aparna Tripathi, Padma V. Devarajan, Ratnesh Jain, Prajakta Dandekar
      Pages 171-196
    7. Devashree Jahagirdar, Sharwari Ghodke, Akshay Mergu, Aishwarya Nikam, Padma V. Devarajan, Ratnesh Jain et al.
      Pages 197-228
    8. Uday Koli, Anomitra Dey, P. Nagendra, Padma V. Devarajan, Ratnesh Jain, Prajakta Dandekar
      Pages 229-268
  4. Receptors and Receptor Mediated Endocytosis in Infectious Diseases

    1. Front Matter
      Pages 269-269
    2. Heena V. Maithania, Anisha A. D’Souza, Prajakta Dandekar, Padma V. Devarajan
      Pages 271-296
    3. Amit S. Lokhande, Priyanka Jahagirdar, Prajakta Dandekar, Padma V. Devarajan
      Pages 297-321
    4. Kritika Gupta, Marianne Saldanha, Mruganka Parasnis, Padma V. Devarajan, Ratnesh Jain, Prajakta Dandekar
      Pages 323-349
  5. Receptor Mediated Endocytosis in Cancer and Infectious Diseases

    1. Front Matter
      Pages 351-351
    2. Saugandha Das, Pawan Kudale, Prajakta Dandekar, Padma V. Devarajan
      Pages 353-381
    3. Darsheen J. Kotak, Pooja A. Todke, Prajakta Dandekar, Padma V. Devarajan
      Pages 383-406
    4. Bhagyashri Joshi, Sukhada S. Shevade, Prajakta Dandekar, Padma V. Devarajan
      Pages 407-431
    5. Priyanka Jahagirdar, Amit S. Lokhande, Prajakta Dandekar, Padma V. Devarajan
      Pages 433-456
    6. Harsh A. Joshi, Esha S. Attar, Prajakta Dandekar, Padma V. Devarajan
      Pages 457-480
  6. Models for Evaluation of Targeted Delivery in Cancer and Infectious Diseases

    1. Front Matter
      Pages 481-481
    2. Vaibhavi Peshattiwar, Aakruti Kaikini, Prajakta Dandekar, Padma V. Devarajan, Sadhana Sathaye
      Pages 483-519
  7. Cellular Assays

    1. Front Matter
      Pages 521-521
    2. Aakruti Kaikini, Vaibhavi Peshattiwar, Padma V. Devarajan, Prajakta Dandekar, Sadhana Sathaye
      Pages 523-544
  8. Back Matter
    Pages 545-560

About this book

Introduction

This book elaborates on various aspects of targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. Many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. An overview of pathways of intracellular uptake is presented with emphasis on RME pathways. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also clinical trials, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. This section also includes a chapter on cellular assays which was conceived to provide hands on training to young and nouveau researchers in the field of targeted nanomedicine. 

Keywords

RME approach cancer therapy substrate ligand binding cellular internalization by receptors infectious disease therapeutics recognition domain of receptors drug discovery and receptors

Editors and affiliations

  • Padma V. Devarajan
    • 1
  • Prajakta Dandekar
    • 2
  • Anisha A. D'Souza
    • 3
  1. 1.Department of Pharmaceutical SciencesInsitute of Chemical Technology Deemed University, Elite Status and Centre of Excellence Government of MaharashtraMumbaiIndia
  2. 2.Department of Pharmaceutical SciencesInsitute of Chemical Technology Deemed University, Elite Status and Centre of Excellence Government of MaharashtraMumbaiIndia
  3. 3.Piramal Enterprises Limited, Pharmaceutical R&DMumbaiIndia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-29168-6
  • Copyright Information American Association of Pharmaceutical Scientists 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-030-29167-9
  • Online ISBN 978-3-030-29168-6
  • Series Print ISSN 2210-7371
  • Series Online ISSN 2210-738X
  • Buy this book on publisher's site