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  • Book
  • © 2019

Phage Therapy: A Practical Approach

  • Presents the topic from the view of the clinical expert

  • Summarises patient treatment and monitoring data and findings

  • Includes contributions dealing with medical policies and regulations

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eBook USD 89.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-26736-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 119.99
Price excludes VAT (USA)
Hardcover Book USD 169.99
Price excludes VAT (USA)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xv
  2. Bacteriophages as Antibacterial Agents

    1. Front Matter

      Pages 1-1
    2. Production of Phage Therapeutics and Formulations: Innovative Approaches

      • Maia Merabishvili, Jean-Paul Pirnay, Kilian Vogele, Danish J. Malik
      Pages 3-41
    3. Phage Pharmacokinetics: Relationship with Administration Route

      • Shigenobu Matsuzaki, Jumpei Uchiyama
      Pages 43-57
    4. Bacterial Resistance to Phage and Its Impact on Clinical Therapy

      • Shawna McCallin, Frank Oechslin
      Pages 59-88
  3. Bacteriophages and the Immune System

    1. Front Matter

      Pages 89-89
    2. Phage Interaction with the Mammalian Immune System

      • Jonas D. Van Belleghem, Krystyna Dąbrowska, Mario Vaneechoutte, Jeremy J. Barr
      Pages 91-122
    3. Humoral Immune Response to Phage-Based Therapeutics

      • Maciej Żaczek, Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Ryszard Międzybrodzki, Wojciech Fortuna, Paweł Rogóż et al.
      Pages 123-143
  4. Use of Bacteriophages to Combat Bacterial Infections

    1. Front Matter

      Pages 145-145
    2. How to Achieve a Good Phage Therapy Clinical Trial?

      • Jérôme Gabard, Patrick Jault
      Pages 147-168
    3. Phage Therapy in Orthopaedic Implant-Associated Infections

      • Paweł Rogóż, Derek F. Amanatullah, Ryszard Międzybrodzki, Robert Manasherob, Nina V. Tikunova, Beata Weber-Dąbrowska et al.
      Pages 189-211
    4. The Use of Bacteriophages in Animal Health and Food Protection

      • Katarzyna Kosznik-Kwaśnicka, Gracja Topka, Aleksandra Dydecka, Agnieszka Necel, Bożena Nejman-Faleńczyk, Sylwia Bloch et al.
      Pages 213-256
    5. Combining Bacteriophages with Other Antibacterial Agents to Combat Bacteria

      • Petar Knezevic, Verica Aleksic Sabo
      Pages 257-293
    6. Phage Therapy of Infectious Biofilms: Challenges and Strategies

      • Luís D. R. Melo, Diana Priscila Pires, Rodrigo Monteiro, Joana Azeredo
      Pages 295-313
  5. Bacteriophage-Derived Antibacterial Agents

    1. Front Matter

      Pages 315-315
    2. Phage Lysins: Novel Alternative to Antibiotics

      • Vincent A. Fischetti
      Pages 317-334
  6. Phage Therapy: Regulatory and Ethical Aspects

    1. Front Matter

      Pages 335-335
    2. Regulatory Considerations for Bacteriophage Therapy Products

      • Roger D. Plaut, Scott Stibitz
      Pages 337-349
    3. Developing Phages into Medicines for Europe

      • Eric Pelfrene, Zigmars Sebris, Marco Cavaleri
      Pages 351-361

About this book

This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail.

This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies.

Keywords

  • viruses infecting bacteria
  • antibiotic resistance
  • phage typing
  • human infection
  • MDR multiple drug resistance

Editors and Affiliations

  • Ludwik Hirszfeld Institute of Immunology, Polish Academy of Sciences, Wroclaw, Poland

    Andrzej Górski, Ryszard Międzybrodzki

  • Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland

    Jan Borysowski

About the editors

Prof.A.Górski, MD, PhD is head of the Bacteriophage Laboratory and Phage Therapy Center.Hismain interests are phage therapy and immunobiology of phage. In the 2000s he presented a hypothesis on protective action of endogenous phages which involves not only their antibacterial but also antiinflammatory and immunomodulatory action. Subsequently, he formulated a hypothesis on phage translocation from the gastrointestinal tract to other tissues where phages could mediate their effects. In the past few years he has published articles envisaging the potential role of phages in the treatment of autoimmune disorders, allergy and graft-versus-host disease (“phage repurposing”)(A.Górski et al., Med Res Rev 2019 doi: 10.1002/med.21593). He was a co-editor of a book on phage therapy (see above).

RyszardMiędzybrodzki MD, PhD has been engaged in preclinical studies on bacteriophage application in the treatment of bacterial infections as well as experimental phage therapy. Since 2013 he has also worked at the Department of Clinical Immunology, Medical University of Warsaw. He has published over 70 papers and five book chapters related to therapeutic phage application including new perspectives of clinical use of bacteriophages (anti-inflammatory and immunomodulating phage effects). He was a co-editor of the book Phage Therapy. Current Research and Applications published in 2014 by Caister Academic Press.

Jan Borysowski MD, PhD works at the Department of Clinical Immunology, Medical University of Warsaw. His interests include phage therapy and medical ethics, especially ethical aspects of compassionate use. He has published over 40 papers and seven book chapters. His papers have been published, among others, by BMC Medicine, Frontiers in Immunology and Frontiers in Microbiology. Moreover, he was the lead editor of the book Phage Therapy. Current Research and Applications published in 2014 by Caister Academic Press.

Bibliographic Information

  • Book Title: Phage Therapy: A Practical Approach

  • Editors: Andrzej Górski, Ryszard Międzybrodzki, Jan Borysowski

  • DOI: https://doi.org/10.1007/978-3-030-26736-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-26735-3

  • Softcover ISBN: 978-3-030-26738-4

  • eBook ISBN: 978-3-030-26736-0

  • Edition Number: 1

  • Number of Pages: XV, 385

  • Number of Illustrations: 2 b/w illustrations, 24 illustrations in colour

  • Topics: Medical Microbiology, Biomedical Research

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-26736-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 119.99
Price excludes VAT (USA)
Hardcover Book USD 169.99
Price excludes VAT (USA)