Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori

  • Steffen Backert

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 421)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Tamaki Ikuse, Thomas G. Blanchard, Steven J. Czinn
    Pages 1-19
  3. Lukas Marcelis, Thomas Tousseyn, Xavier Sagaert
    Pages 77-106
  4. Médea Padra, John Benktander, Karen Robinson, Sara K. Lindén
    Pages 179-207
  5. Suneesh Kumar Pachathundikandi, Nicole Blaser, Steffen Backert
    Pages 267-302
  6. M. Blanca Piazuelo, Rachel P. Riechelmann, Keith T. Wilson, Holly M. Scott Algood
    Pages 319-359

About this book


This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world’s population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection.

This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.


Helicobacter pylori gastric inflammation peptic ulcer gastritis gastric cancer gastric microbiome

Editors and affiliations

  • Steffen Backert
    • 1
  1. 1.Division of Microbiology, Department of BiologyUniversity of Erlangen-Nuremberg ErlangenGermany

Bibliographic information