Direct Mechanisms in Cholesterol Modulation of Protein Function

  • Avia Rosenhouse-Dantsker
  • Anna N. Bukiya

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1135)

Table of contents

  1. Front Matter
    Pages i-ix
  2. General Characteristics of Cholesterol Binding Sites

    1. Front Matter
      Pages 1-1
    2. Jacques Fantini, Richard M. Epand, Francisco J. Barrantes
      Pages 3-25
    3. Jessica Ounjian, Anna N. Bukiya, Avia Rosenhouse-Dantsker
      Pages 47-66
    4. Cong Wang, Arthur Ralko, Zhong Ren, Avia Rosenhouse-Dantsker, Xiaojing Yang
      Pages 67-86
  3. Cholesterol Binding Sites in Proteins: Case Studies

    1. Front Matter
      Pages 87-87
    2. Sofia Kiriakidi, Antonios Kolocouris, George Liapakis, Saima Ikram, Serdar Durdagi, Thomas Mavromoustakos
      Pages 89-103
    3. Sara L. Morales-Lázaro, Tamara Rosenbaum
      Pages 105-117
    4. Stephanie M. Cologna, Avia Rosenhouse-Dantsker
      Pages 139-160
  4. Back Matter
    Pages 161-168

About this book


In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis.  

Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins.

The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.


cholesterol modulation protein function cholesterol binding steroid-protein interaction lipid membranes

Editors and affiliations

  • Avia Rosenhouse-Dantsker
    • 1
  • Anna N. Bukiya
    • 2
  1. 1.Department of ChemistryUniversity of IllinoisChicagoUSA
  2. 2.Department of PharmacologyThe University of Tennessee HSCMemphisUSA

Bibliographic information