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  • Book
  • © 2019

Hypoxia and Cancer Metastasis

  • Focuses on understanding the negative impact of hypoxia in cancer progression

  • Describes how hypoxia promotes key events that lead to cancer metastasis

  • Provides current approaches used clinically and pre-clinically to identify and target hypoxic cancer cells

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1136)

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eBook USD 119.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-12734-3
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 159.99
Price excludes VAT (USA)
Hardcover Book USD 159.99
Price excludes VAT (USA)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
  2. Clinical and Pre-clinical Methods for Quantifying Tumor Hypoxia

    • Ashlyn G. Rickard, Gregory M. Palmer, Mark W. Dewhirst
    Pages 19-41
  3. Hypoxia-Induced Phenotypes that Mediate Tumor Heterogeneity

    • Jin Qian, Erinn B. Rankin
    Pages 43-55
  4. Hypoxia and the Tumor Secretome

    • Ying Liu, Gabrielle E. Ciotti, T. S. Karin Eisinger-Mathason
    Pages 57-69
  5. Hypoxia and Metabolism in Metastasis

    • Tong Zhang, Caixia Suo, Chenyang Zheng, Huafeng Zhang
    Pages 87-95
  6. Hypoxia and the Metastatic Niche

    • Cerise Yuen-Ki Chan, Vincent Wai-Hin Yuen, Carmen Chak-Lui Wong
    Pages 97-112
  7. Mechanistic Justifications of Systemic Therapeutic Oxygenation of Tumors to Weaken the Hypoxia Inducible Factor 1α-Mediated Immunosuppression

    • Stephen Hatfield, Katarina Veszeleiova, Joe Steingold, Jyothi Sethuraman, Michail Sitkovsky
    Pages 113-121
  8. Hypoxia-Induced Resistance to Chemotherapy in Cancer

    • Lori M. Minassian, Tiziana Cotechini, Erin Huitema, Charles H. Graham
    Pages 123-139
  9. Therapeutic Strategies to Block the Hypoxic Response

    • Josh W. DiGiacomo, Daniele M. Gilkes
    Pages 141-157
  10. Back Matter

    Pages 159-160

About this book

The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions.

Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments.

This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.


Keywords

  • hypoxia
  • cancer
  • HIF
  • metastasis
  • angiogenesis

Editors and Affiliations

  • Breast and Ovarian Cancer Program, Department of Oncology, The Johns Hopkins School of Medicine, Baltimore, USA

    Daniele M. Gilkes

About the editor

Assistant Professor of Oncology
Assistant Professor Chemical and Molecular Engineering
Johns Hopkins University School of Medicine
Baltimore, Maryland
Jayne Koskinas Ted Giovanis Foundation for Health and Policy Partnership

Daniele Gilkes earned her MS in engineering from the University of Florida and her PhD in cancer biology from the University of South Florida. She is currently an assistant professor in the departments of Oncology as well as Chemical and Molecular Engineering at the Johns Hopkins University School of Medicine. Her research goal is to develop a breast cancer research program which utilizes new technologies that can rapidly advance our understanding of how the microenvironment, in particular hypoxia and hypoxia-induced genetic changes, promote breast cancer metastasis. The overall objective is to identify therapeutic strategies that focus on metastasis treatment and prevention strategies for breast cancer patients.

Current Research
Seeking to understand the timing and requirements for metastasis.
Using both mathematics and cancer biology to chart the process of metastasis.
These innovate cross-disciplinary studies will accelerate our understanding of metastasis and guide new therapy development to prevent metastasis in breast cancer survivors.

Bibliographic Information

Buying options

eBook USD 119.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-12734-3
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 159.99
Price excludes VAT (USA)
Hardcover Book USD 159.99
Price excludes VAT (USA)