Hypoxia and Cancer Metastasis

  • Daniele M. Gilkes

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1136)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Ashlyn G. Rickard, Gregory M. Palmer, Mark W. Dewhirst
    Pages 19-41
  3. Jin Qian, Erinn B. Rankin
    Pages 43-55
  4. Ying Liu, Gabrielle E. Ciotti, T. S. Karin Eisinger-Mathason
    Pages 57-69
  5. Tong Zhang, Caixia Suo, Chenyang Zheng, Huafeng Zhang
    Pages 87-95
  6. Cerise Yuen-Ki Chan, Vincent Wai-Hin Yuen, Carmen Chak-Lui Wong
    Pages 97-112
  7. Stephen Hatfield, Katarina Veszeleiova, Joe Steingold, Jyothi Sethuraman, Michail Sitkovsky
    Pages 113-121
  8. Lori M. Minassian, Tiziana Cotechini, Erin Huitema, Charles H. Graham
    Pages 123-139
  9. Josh W. DiGiacomo, Daniele M. Gilkes
    Pages 141-157
  10. Back Matter
    Pages 159-160

About this book


The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions.

Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments.

This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.


hypoxia cancer HIF metastasis angiogenesis

Editors and affiliations

  • Daniele M. Gilkes
    • 1
  1. 1.Breast and Ovarian Cancer Program, Department of OncologyThe Johns Hopkins School of MedicineBaltimoreUSA

Bibliographic information