Contains new chapters of how treatment can be applied for major disease areas
Provides a background to aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes
Aids the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans?
Provides practical examples to assist usage/applications, explanation and study analysis
Perils and pitfalls are summarized for each technique
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Table of contents (20 chapters)
Review of Clinical Investigative Methods
Preclinical Drug Development and Transitioning to Clinical Studies
About this book
This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders.
Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs.
This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders.
Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
- non-alcoholic fatty liver disease
- glucose-lowering drugs
- glucose clamp
- insulin resistance
- cardiometabolic disease
- metabolic disease
Editors and Affiliations
ProSciento, Chula Vista, USA
Andrew J. Krentz, Christian Weyer, Marcus Hompesch
About the editors
Book Title: Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease
Book Subtitle: A Focus on Early Phase Clinical Drug Development
Editors: Andrew J. Krentz, Christian Weyer, Marcus Hompesch
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-11747-4Published: 12 April 2019
eBook ISBN: 978-3-030-11748-1Published: 02 April 2019
Edition Number: 2
Number of Pages: XI, 556
Number of Illustrations: 56 b/w illustrations, 59 illustrations in colour
Topics: Diseases, Pharmacology