Management of Myocardial Reperfusion Injury

  • Juan Carlos Kaski
  • Derek J. Hausenloy
  • Bernard John Gersh
  • Derek M. Yellon

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Derek J. Hausenloy, Juan Carlos Kaski, Bernard John Gersh, Derek M. Yellon
      Pages 3-8
  3. The Pathophysiology of Myocardial Reperfusion Injury: From a Pre-clinical Phenomenon to a New Target for Cardioprotection

    1. Front Matter
      Pages 9-9
    2. James M. Downey, Michael V. Cohen
      Pages 11-28
    3. Jakob Vinten-Johansen, Amanda J. Zatta, Rong Jiang, Weiwei Shi
      Pages 51-85
    4. Nathan Mewton, François Roubille, Olivier Lairez, Gilles Rioufol, Meyer Elbaz, Christophe Piot et al.
      Pages 87-99
  4. Diagnosis of Myocardial Reperfusion Injury: Assessment and Quantification

    1. Front Matter
      Pages 101-101
    2. Eva von Schmilowski, Howard Swanton
      Pages 103-133
    3. Mariana Mirabel, Denis Pellerin
      Pages 135-159
    4. Victoria Delgado, Arend F. L. Schinkel, Kai-Hang Yiu, Jeroen J. Bax
      Pages 161-189
  5. Management of Myocardial Reperfusion Injury

    1. Front Matter
      Pages 213-213
    2. Wichert J. Kuijt, Judson Williams, Christopher B. Granger, Mitchell W. Krucoff, Matthew T. Roe
      Pages 215-238
    3. Abhiram Prasad, Bernard John Gersh
      Pages 239-260
    4. Derek J. Hausenloy, Derek M. Yellon
      Pages 261-291
    5. Derek J. Hausenloy, Juan Carlos Kaski, Bernard John Gersh, Derek M. Yellon
      Pages 293-295
  6. Back Matter
    Pages 297-305

About this book


Much has been written about myocardial reperfusion injury and the controversies surrounding its existence and clinical relevance in the past 20 to 30 years. Unfortunately, however, there is little published information that integrates research findings with the practical aspects of its management and this has hindered the analysis of the clinical impact of the condition and its management.

The pathophysiology and molecular mechanisms of myocardial reperfusion injury are complex, while individual diagnostic techniques have been proposed but without a proper assessment of the relative values of these methods.  The management of this condition has also been problematic, as therapeutic strategies that demonstrate prevention of myocardial reperfusion injury in experimental models have not translated into beneficial treatment strategies for patients.

Management of Myocardial Reperfusion Injury brings together leading cardiovascular researchers and cardiologists to provide a comprehensive and critical review of the issues.  Existing and novel therapeutic strategies for preventing myocardial reperfusion injury are discussed in depth, which will result in this being a vital reference for cardiologists and all healthcare professionals with an interest in the pathogenesis and management of myocardial damage. Cardiologists in training will find this monographic work to be an invaluable formative tool.  This book will hopefully assist in further reducing the morbidity and mortality resulting from acute myocardial infarction.


Myocardial Reperfusion Injury

Editors and affiliations

  • Juan Carlos Kaski
    • 1
  • Derek J. Hausenloy
    • 2
  • Bernard John Gersh
    • 3
  • Derek M. Yellon
    • 4
  1. 1.Medical School, Coronary Artery Disease, Research GroupSt George's HospitalLondonUnited Kingdom
  2. 2.Hatter Cardiovascular Inst., Div. MedicineUniversity College LondonLondonUnited Kingdom
  3. 3.Mayo Graduate School of Medicine, Dept. Cardiovascular DiseasesMayo ClinicRochesterUSA
  4. 4.Hatter Cardiovascular InstituteUniversity College LondonLondonUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag London 2012
  • Publisher Name Springer, London
  • eBook Packages Medicine
  • Print ISBN 978-1-84996-018-2
  • Online ISBN 978-1-84996-019-9
  • Buy this book on publisher's site