Bone and Osteoarthritis

  • Felix Bronner
  • Mary C. Farach-Carson

Part of the Topics in Bone Biology book series (TBB, volume 4)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Helmtrud I. Roach, Simon Tilley
    Pages 1-18
  3. Daniel Lajeunesse, Pascal Reboul
    Pages 19-39
  4. Arjen B. Blom, Wim B. van den Berg
    Pages 65-79
  5. Dick Heinegård
    Pages 81-95
  6. Naoshi Fukui, Linda J. Sandell
    Pages 97-108
  7. Irving M. Shapiro, Christopher S. Adams, Vickram Srinivas, Theresa A. Freeman
    Pages 109-129
  8. Kay E. Chapman, Helmtrud I Roach
    Pages 131-148
  9. Alison M. Bendele
    Pages 149-163
  10. Diana H. Chai, Anna L. Stevens, Alan J. Grodzinsky
    Pages 165-179
  11. Clifton O. Bingham
    Pages 181-197
  12. Back Matter
    Pages 199-215

About this book


Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease.

A novel aspect is the attention given to the possible epigenetic basis, together with a discussion of the genetics predisposing to osteoarthritis.

Detailed analyses are given of the role of the synovium, of the molecular mechanisms that lead to degradation of the cartilage matrix, of the hypertrophy of the cartilage cell, of the anabolic and catabolic roles of cytokines, may lead to novel approaches to clinical treatment, utilizing anabolic mediators or molecules that target steps in the disease process. Also discussed are animal models and how mechano-responsiveness is compromised by mechanical injury.

Orthopedics and rheumatology have become close conceptually, as advances in bone and joint biology have enabled bench and translational scientists, as well as practitioners, to approach clinical problems comprehensively. Because bone plays a role in initiating osteoarthritis, therapeutic approaches focusing on bone tissue are included in the discussion of novel treatments. The general topic of osteoarthritis is therefore a timely subject for a series on bone biology.

This book, intended for clinicians, researchers and students, provides information that will orient the novice and update the specialist. No other book treats the relationship of bone to osteoarthritis in similar fashion or provides a comparable underpinning of joint pathophysiology.


Arthritis Osteoarthritis biomechanics bone cartilage geriatrics oncology pathophysiology physiology

Editors and affiliations

  • Felix Bronner
    • 1
  • Mary C. Farach-Carson
    • 2
  1. 1.University of Connecticut Health CenterFarmingtonUSA
  2. 2.Department of Biological SciencesUniversity of DelawareNewarkUSA

Bibliographic information