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Tandem Repeats in Genes, Proteins, and Disease

Methods and Protocols

  • Danny M. Hatters
  • Anthony J. Hannan

Part of the Methods in Molecular Biology book series (MIMB, volume 1017)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Andrey S. Tsvetkov, D. Michael Ando, Steven Finkbeiner
    Pages 1-20
  3. Wan Song, Marianne R. Smith, Adeela Syed, Tamas Lukacsovich, Brett A. Barbaro, Judith Purcell et al.
    Pages 41-57
  4. T. R. Mattiske, May H. Tan, Jozef Gécz, Cheryl Shoubridge
    Pages 121-133
  5. S. E. Samaraweera, L. V. O’Keefe, C. L. van Eyk, K. T. Lawlor, D. T. Humphreys, C. M. Suter et al.
    Pages 173-192
  6. Regina M. Murphy
    Pages 201-217
  7. Eric D. Ross, Kyle S. MacLea, Charles Anderson, Asa Ben-Hur
    Pages 219-228
  8. Back Matter
    Pages 255-258

About this book

Introduction

The genomes of humans, as well as many other species, are interspersed with hundreds of thousands of tandem repeats of DNA sequences.  Those tandem repeats located as codons within open reading frames encode amino acid runs, such as polyglutamine and polyalanine.  Tandem repeats have not only been implicated in biological evolution, development and function but also in a large collection of human disorders. In Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols, expert researchers in the field detail many methods covering the analysis of tandem repeats in DNA, RNA and protein, in healthy and diseased states.  This will include molecular genetics, molecular biology, biochemistry, proteomics, biophysics, cell biology, and molecular  and cellular approaches to animal models of tandem repeat disorders. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 

Authoratative and Practical, Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols aids scientists in continuing to study the unique methodological challenges that come from repetitive DNA and poly-amino acid sequences.

Keywords

DNA sequences animal models of tandem cellular approaches codons human disorders poly-amino acid sequences tandem repeats in DNA tandem repeats in RNA

Editors and affiliations

  • Danny M. Hatters
    • 1
  • Anthony J. Hannan
    • 2
  1. 1., Dept. of Biochemistry and Molecular BiolThe University of MelbourneParkvilleAustralia
  2. 2.Florey Neuroscience Institutes, and Mental HealthThe University of MelbourneParkvilleAustralia

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-62703-438-8
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-437-1
  • Online ISBN 978-1-62703-438-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site