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  • © 2012

Rational Drug Design

Methods and Protocols

Editors:

  • Aids scienctist in further study of rational drug design
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 928)

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Table of contents (17 protocols)

  1. Front Matter

    Pages i-xi
  2. On Setting Up and Assessing Docking Simulations for Virtual Screening

    • Jacek Biesiada, Aleksey Porollo, Jaroslaw Meller
    Pages 1-16
  3. Rational Design of Rho GTPase-Targeting Inhibitors

    • Xun Shang, Yi Zheng
    Pages 29-38
  4. Rational Design of Peptide Ligands Against a Glycolipid by NMR Studies

    • Wenyong Tong, Tara Sprules, Kalle Gehring, H. Uri Saragovi
    Pages 39-52
  5. A Combinatorial Strategy for the Acquisition of Potent and Specific Protein Tyrosine Phosphatase Inhibitors

    • Sheng Zhang, Lan Chen, David S. Lawrence, Zhong-Yin Zhang
    Pages 53-65
  6. Identification of Allosteric Inhibitors of p21-Activated Kinase

    • Julien Viaud, Jeffrey R. Peterson
    Pages 67-79
  7. Random Mutagenesis of Peptide Aptamers as an Optimization Strategy for Inhibitor Screening

    • Nathalie Bouquier, Sylvie Fromont, Anne Debant, Susanne Schmidt
    Pages 97-118
  8. Purification and Specific Assays for Measuring APE-1 Endonuclease Activity

    • Adrian Esqueda, Mohammed Z. Mohammed, Srinivasan Madhusudan, Nouri Neamati
    Pages 161-174
  9. Mouse Models for Tumor Metastasis

    • Shengyu Yang, J. Jillian Zhang, Xin-Yun Huang
    Pages 221-228
  10. Back Matter

    Pages 229-230

About this book

Over the past  three decades there have been new developments in therapeutic drug design. In Rational Drug Design: Methods and Protocols,  expert researchers in the field detail many of the methodologies used to study rational drug design. These include methods such as virtual screening of chemical hits, rational lead discovery by high throughput screening, combinatorial and fragment based lead generation, peptide based drug discovery, and animal models of lead validation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and practical, Rational Drug Design: Methods and Protocols seeks to aid scientists in the further study of rational drug design and future drug discovery.

Reviews

From the reviews:

“This book covers some of the tools and techniques involved in rational drug design with a series of case studies designed to act as a compendium of methods and protocols intended for readers to adopt or modify. … The book would therefore make interesting reading to any student or investigator looking to gain a wider appreciation of strategies and activities across different disciplines or unfamiliar projects in the early drug discovery phase as well as the primary target audience of organic/medicinal chemists and molecular biologists.” (Stefan Kavanagh, BTS Newsletter – The British Toxicology Society, Issue 43, Winter, 2013)

Editors and Affiliations

  • Research Foundation, Div. Experimental Hematology, Cincinnati Children's Hospital, Cincinnati, USA

    Yi Zheng

Bibliographic Information

  • Book Title: Rational Drug Design

  • Book Subtitle: Methods and Protocols

  • Editors: Yi Zheng

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-62703-008-3

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2012

  • Hardcover ISBN: 978-1-62703-007-6Published: 06 September 2012

  • Softcover ISBN: 978-1-4939-5900-6Published: 23 August 2016

  • eBook ISBN: 978-1-62703-008-3Published: 06 September 2012

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 230

  • Number of Illustrations: 36 b/w illustrations, 22 illustrations in colour

  • Topics: Pharmacology/Toxicology, Medicinal Chemistry

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access