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Rational Drug Design

Methods and Protocols

  • Yi Zheng

Part of the Methods in Molecular Biology book series (MIMB, volume 928)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Jacek Biesiada, Aleksey Porollo, Jaroslaw Meller
    Pages 1-16
  3. Xun Shang, Yi Zheng
    Pages 29-38
  4. Wenyong Tong, Tara Sprules, Kalle Gehring, H. Uri Saragovi
    Pages 39-52
  5. Sheng Zhang, Lan Chen, David S. Lawrence, Zhong-Yin Zhang
    Pages 53-65
  6. Julien Viaud, Jeffrey R. Peterson
    Pages 67-79
  7. Nathalie Bouquier, Sylvie Fromont, Anne Debant, Susanne Schmidt
    Pages 97-118
  8. Adrian Esqueda, Mohammed Z. Mohammed, Srinivasan Madhusudan, Nouri Neamati
    Pages 161-174
  9. Shengyu Yang, J. Jillian Zhang, Xin-Yun Huang
    Pages 221-228
  10. Back Matter
    Pages 229-230

About this book

Introduction

Over the past  three decades there have been new developments in therapeutic drug design. In Rational Drug Design: Methods and Protocols,  expert researchers in the field detail many of the methodologies used to study rational drug design. These include methods such as virtual screening of chemical hits, rational lead discovery by high throughput screening, combinatorial and fragment based lead generation, peptide based drug discovery, and animal models of lead validation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and practical, Rational Drug Design: Methods and Protocols seeks to aid scientists in the further study of rational drug design and future drug discovery.

Keywords

ATP binding GTPases Structure based virtual screening anti-sense microRNA drug discovery drug resistance molecular biology phosphotases rational designed wnt pathway targets

Editors and affiliations

  • Yi Zheng
    • 1
  1. 1.Research Foundation, Div. Experimental HematologyCincinnati Children's HospitalCincinnatiUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-62703-008-3
  • Copyright Information Springer Science+Business Media New York 2012
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-007-6
  • Online ISBN 978-1-62703-008-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site