Photosensitive Molecules for Controlling Biological Function

  • James J. Chambers
  • Richard H. Kramer

Part of the Neuromethods book series (NM, volume 55)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Photoreactive Small Molecules for Affecting Biological Function

    1. Front Matter
      Pages 1-1
    2. James J. Chambers, Richard H. Kramer
      Pages 3-5
    3. Graham C. R. Ellis-Davies
      Pages 39-56
  3. Imparting Light Sensitivity on Cells Using Photosensitive Proteins

    1. Front Matter
      Pages 93-93
    2. James J. Chambers, Richard H. Kramer
      Pages 95-97
    3. Brian Y. Chow, Xue Han, Jacob G. Bernstein, Patrick E. Monahan, Edward S. Boyden
      Pages 99-132
    4. Davina V. Gutierrez, Eugene Oh, Stefan Herlitze
      Pages 133-146
  4. Molecular Photoswitch Conjugates to Remotely Affect Activity

    1. Front Matter
      Pages 165-165
    2. James J. Chambers, Richard H. Kramer
      Pages 167-169
    3. Andrew A. Beharry, G. Andrew Woolley
      Pages 171-184
    4. Doris L. Fortin, Richard H. Kramer
      Pages 185-212
    5. Harald Janovjak, Ehud Y. Isacoff
      Pages 233-266
    6. Pau Gorostiza, Ehud Y. Isacoff
      Pages 267-285
  5. Back Matter
    Pages 287-297

About this book


The development of new photochemical tools, some synthesized by chemists and some provided by nature, is rapidly changing the way neurobiological research is performed in the modern laboratory.  In Photosensitive Molecules for Controlling Biological Function, expert researchers in the field examine the most cutting-edge tools currently available.  Divided into three sections, this detailed compendium features techniques involving natural photosensitive proteins, caged neurotransmitters, and small molecule photoswitches that bestow light sensitivity on ion channels and receptors.  Written for the Neuromethods series, this volume features the type of meticulous description and implementation advice that is crucial for getting optimal results in the lab.


Authoritative and practical, Photosensitive Molecules for Controlling Biological Function provides an unbiased comparison of the various photochemical tools currently available for controlling neuronal activity in order to aid scientists in the vital goal of choosing the right tools for the right job.


Caged neurotransmitters Light delivery Neural function Photochemical tools Photoresponsive proteins Small molecule photoswitches Synthetic chemistry

Editors and affiliations

  • James J. Chambers
    • 1
  • Richard H. Kramer
    • 2
  1. 1., Department of ChemistryUniversity of Massachusetts, AmherstAmherstUSA
  2. 2., Dept. of Molecular and Cell BiologyUniversity of California, BerkeleyBerkeleyUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-030-0
  • Online ISBN 978-1-61779-031-7
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site