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Drug Design and Discovery

Methods and Protocols

  • Seetharama D. Satyanarayanajois

Part of the Methods in Molecular Biology book series (MIMB, volume 716)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Yat T. Tang, Garland R. Marshall
    Pages 1-22
  3. Mudit Mudit, Mohammad Khanfar, Girish V. Shah, Khalid A. El Sayed
    Pages 55-71
  4. Justin K. Murray, Jennifer Aral, Les P. Miranda
    Pages 73-88
  5. Jatinder S. Josan, Channa R. De Silva, Byunghee Yoo, Ronald M. Lynch, Mark D. Pagel, Josef Vagner et al.
    Pages 89-126
  6. Ng Jin Kiat, Fritz Simeon, Too Heng Phon, Parayil Kumaran Ajikumar
    Pages 127-140
  7. Saleem Basha, Shruthi Vaidhyanathan, Giovanni M. Pauletti
    Pages 141-156
  8. Delira Robbins, Yunfeng Zhao
    Pages 169-177
  9. Vineet Gupta, Qian-Jin Zhang, Yong-Yu Liu
    Pages 179-191
  10. Hanbing Zhong, Shuo Lin
    Pages 193-205
  11. Seetharama D. Satyanarayanajois, Sharon Ronald, Jining Liu
    Pages 225-243
  12. Ramar Perumal Samy, Maung Maung Thwin, Vincent T. K. Chow, Ho Bow, Ponnampalam Gopalakrishnakone
    Pages 245-265
  13. Back Matter
    Pages 281-284

About this book

Introduction

Research in the pharmaceutical sciences and medicinal chemistry has taken an important new direction in the past two decades with a focus on large molecules, especially peptides and proteins, as well as DNA therapeutics.  In Drug Design and Discovery: Methods and Protocols, leading experts provide an in-depth view of key protocols that are commonly used in drug discovery laboratories.  Covering both classic and cutting-edge techniques, this volume explores computational docking, quantitative structure-activity relationship (QSAR), peptide synthesis, labeling of peptides and proteins with fluorescent labels, DNA-microarray, zebrafish model for drug screening, and other analytical screening and biological assays that are routinely used during the drug discovery process.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Thorough and accessible, Drug Design and Discovery: Methods and Protocols serve as a vital laboratory reference for pharmaceutical chemists, medicinal chemists, and pharmacologists as well as for molecular biologists.

Keywords

Drug screening Lead compounds Pharmacokinetics Protein and peptide drugs Protein-protein interactions Target identification Therapeutic agents Toxicology and toxicity

Editors and affiliations

  • Seetharama D. Satyanarayanajois
    • 1
  1. 1.College of Pharmacy, Dept. Basic Pharmaceutical SciencesUniversity of Louisiana at MonroeMonroeUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-61779-012-6
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-011-9
  • Online ISBN 978-1-61779-012-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site