Animal Models of Dementia

  • Peter Paul De Deyn
  • Debby Van Dam

Part of the Neuromethods book series (NM, volume 48)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Animal Modeling: General and Ethical Aspects and Drug Discovery Pipeline

    1. Front Matter
      Pages 1-1
    2. Peter Paul De Deyn, Debby Van Dam
      Pages 3-13
    3. I. Anna S. Olsson, Peter Sandøe
      Pages 15-33
    4. Debby Van Dam, Peter Paul De Deyn
      Pages 35-49
  3. Methodological Considerations when Developing Animal Models of Dementia

    1. Front Matter
      Pages 51-51
    2. Annemie Van Dijck, Debby Van Dam, Peter Paul De Deyn
      Pages 53-75
    3. Susan L. Stoddard, James A. Rogers III
      Pages 91-96
  4. Validation of Animal Models of Dementia

    1. Front Matter
      Pages 97-97
    2. Daniel Pirici, Christine Van Broeckhoven, Samir Kumar-Singh
      Pages 99-141
    3. Debby Van Dam, Annemie Van Dijck, Peter Paul De Deyn
      Pages 143-154
    4. Giancarlo Pepeu, Maria Cristina Rosi
      Pages 169-185
    5. Greet Vanhoutte, Adriaan Campo, Annemie Van der Linden
      Pages 187-220
  5. Animal Models of Alzheimer’s Disease

    1. Front Matter
      Pages 221-221
    2. Maria E. Giannakou, Damian C. Crowther
      Pages 223-240
    3. Tjakko J. Van Ham, Ellen A. A. Nollen
      Pages 241-253
    4. Rob Willemsen, Sandra van’t Padje, John C. van Swieten, Ben A. Oostra
      Pages 255-269

About this book

Introduction

With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Keywords

Alzheimer’s disease Brain diseases Cognitive impairment Drug discovery and development Neurodegeneration Neurological disorders New therapeutic targets Preclinical research Vascular dementia

Editors and affiliations

  • Peter Paul De Deyn
    • 1
  • Debby Van Dam
    • 2
  1. 1.Institute Born-Bunge, Lab of Neurochemistry & BehaviourUniversity of AntwerpWilrijkBelgium
  2. 2.Institute Born-Bunge, Lab of Neurochemistry & BehaviourUniversity of AntwerpWilrijkBelgium

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-898-0
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-897-3
  • Online ISBN 978-1-60761-898-0
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • About this book