Overview
- Presents easy-to-use, comprehensive, and fully updated techniques to study MAPKs
- Serves a wide variety of scientists, from cellular biologists and biochemists to disease specialists seeking cures to diabetes, inflammation, and cancer
- Provides tips on troubleshooting difficult aspects of the included protocols
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 661)
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About this book
Mitogen-activated protein (MAP) kinase (MAPK) cascades are key signaling components that govern essentially all cellular processes evoked by any type of stimulation, and it has been well established that the malfunctioning of these cascades leads to various diseases including cancer, autoimmunity, and diabetes. In MAP Kinase Signaling Protocols, Second Edition, expert researchers fully update the popular first edition the key techniques used in the study of MAPK signaling cascades in various cellular contexts. This thorough volume explores essential topics such as activation and function of components of the MAPK signaling cascades, the study of MAPK cascades as transmitters of membranal receptor signals, structure-function relationships of MAPKs, studies on the regulation of MAPK cascades, the use of lower organisms, animal models, and human genetics in the study of MAPKs, as well as the study of MAPKs in specific systems and diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters includes introductions to their respective subjects, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and cutting-edge, MAP Kinase Signaling Protocols, Second Edition aims to facilitate the study of MAPKs and allow for quicker progress in our knowledge of many vital cellular processes as well as devastating diseases.
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Keywords
Table of contents (32 protocols)
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Front Matter
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Activation and Function of Components of the MAP Kinase Signaling Cascades
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Front Matter
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Study of MAP Kinase Cascades as Transmitters of Membranal Receptor Signals
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Front Matter
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Structure-Function Relationships and Localization of MAP Kinases
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Front Matter
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Editors and Affiliations
Bibliographic Information
Book Title: MAP Kinase Signaling Protocols
Editors: Rony Seger
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-60761-795-2
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC 2010
Hardcover ISBN: 978-1-60761-794-5Published: 09 September 2010
Softcover ISBN: 978-1-4939-6105-4Published: 23 August 2016
eBook ISBN: 978-1-60761-795-2Published: 02 September 2010
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 2
Number of Pages: XIV, 529
Topics: Cell Biology