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Rodent Models of Stroke

  • Ulrich Dirnagl

Part of the Neuromethods book series (NM, volume 47)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Ludmila Belayev, Matthias Endres, Vincent Prinz
    Pages 29-40
  3. Cyrille Orset, Benoit Haelewyn, Kilian Vivien, Denis Vivien, Alan R. Young
    Pages 55-70
  4. Barry McColl, David Howells, Nancy Rothwell, Adam Denes
    Pages 93-119
  5. Richard J. Traystman
    Pages 121-138
  6. Andreas Wunder, Jan Klohs
    Pages 167-177
  7. Mustafa Balkaya, Matthias Endres
    Pages 179-197
  8. Gerlinde A. S. Metz
    Pages 199-212
  9. Clemens Sommer
    Pages 213-226
  10. Back Matter
    Pages 279-286

About this book

Introduction

In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors’ longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.

Keywords

Brain and spinal cord injury Focal cerebral ischemia Neurological injury Neuroprotection Stroke modeling physiology

Editors and affiliations

  • Ulrich Dirnagl
    • 1
  1. 1.Charité Campus Mitte, Centrum für Schlaganfall-ForschungCharité - Universitätsmedizin BerlinBerlinGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-750-1
  • Copyright Information Springer Science + Business Media, LLC 2010
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-749-5
  • Online ISBN 978-1-60761-750-1
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site