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  • © 2010

Hormesis

A Revolution in Biology, Toxicology and Medicine

  • Groundbreaking coverage of an oft experienced, but poorly understood phenomenon that affects all forms of life on earth

  • Explains why the principle of hormesis is important to our health, our environment, and the future of our planet

  • Provides specific examples of biphasic dose responses and their importance for the fields of biology, medicine and environmental safety

  • Discusses how knowledge of hormesis is being applied to research aimed understanding the organization and function of biological systems

  • Illustrates how disorders such as diabetes, obesity and cardiovascular disease result from the lack of exposure to beneficial environmental stresses

  • Considers the implications of the cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations

  • Includes supplementary material: sn.pub/extras

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • ISBN: 978-1-60761-495-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 219.99
Price excludes VAT (USA)
Hardcover Book USD 249.99
Price excludes VAT (USA)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiv
  2. Hormesis: What it is and Why it Matters

    • Mark P. Mattson, Edward J. Calabrese
    Pages 1-13
  3. The Fundamental Role of Hormesis in Evolution

    • Mark P. Mattson
    Pages 57-68
  4. Transcriptional Mediators of Cellular Hormesis

    • Tae Gen Son, Roy G. Cutler, Mark P. Mattson, Simonetta Camandola
    Pages 69-93
  5. The Devil is in the Dose: Complexity of Receptor Systems and Responses

    • Wayne Chadwick, Stuart Maudsley
    Pages 95-108
  6. Exercise-Induced Hormesis

    • Alexis M. Stranahan, Mark P. Mattson
    Pages 109-122
  7. Dietary Energy Intake, Hormesis, and Health

    • Bronwen Martin, Sunggoan Ji, Caitlin M. White, Stuart Maudsley, Mark P. Mattson
    Pages 123-137
  8. Couch Potato: The Antithesis of Hormesis

    • Mark P. Mattson, Alexis Stranahan, Bronwen Martin
    Pages 139-151
  9. Hormesis and Aging

    • Suresh I. S. Rattan, Dino Demirovic
    Pages 153-175
  10. Back Matter

    Pages 199-213

About this book

Hormesis is defined as any circumstance in which exposure of a cell or organism to a low dose of a substance or condition results in an adaptive stimulatory/beneficial outcome, while exposure to a high dose results in an inhibitory / detrimental outcome. When plotted on a graph the shape of the dose response curve is biphasic, the hallmark of hormesis. This groundbreaking book "Hormesis: A Revolution in Biology, Toxicology and Medicine" describes why and how hormesis is a fundamental feature of all living systems and is based on the evolutionary principle of selection for genetic traits that confer the ability to respond adaptively to adverse environmental conditions. Using numerous specific examples the authors explain why knowledge of hormesis is important for our health, our environment, and the future of our planet. Several chapters of the book describe emerging research findings that elucidate the molecular and cellular underpinnings of the biphasic dose response/hormesis. The implications of the tapping of cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations are described.

From environmental protection policy to medical practice, it is critical that leaders recognize and understand hormesis, and incorporate it into their decision making process. The authors propose that the prevention of major diseases, including diabetes, obesity and cardiovascular disease can be achieved using hormetic approaches. Scientists, physicians, environmental gurus and anyone interested in the science underlying biology and medicine will benefit from reading this book.

Features

  • Groundbreaking coverage of an oft experienced, but poorly understood phenomenon that affects all forms of life on earth.
  • Explains why the principle of hormesis is important to our health, our environment, and the future of our planet.
  • Provides specific examples of biphasic dose responses and their importance for the fields of biology, medicine and environmental safety.
  • Discusses how knowledge of hormesis is being applied to research aimed understanding the organization and function of biological systems.
  • Illustrates how disorders such as diabetes, obesity and cardiovascular disease result from the lack of exposure to beneficial environmental stresses.
  • Considers the implications of the cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations.

Keywords

  • aging
  • assessment
  • biology
  • cardiovascular disease
  • cell
  • cells
  • environment
  • environmental protection
  • evolution
  • evolutionary biology
  • gerontology
  • pharmacology
  • research
  • toxicology
  • transcription

Reviews

From the reviews:

“‘Hormesis: a revolution in biology, toxicology and medicine’ is a very interesting and well- written book organized by two expressive authors in neuroscience and the health environment. … The book is divided into 10 chapters, each written by a group of authors, describing the concept of hormesis … . book concludes by proposing a fresh look at the modern pharmacy of natural products and man-made drugs. It is a pleasant read for anyone interested in toxicology, environmental health and pharmacology.” (Tania Marcourakis, Brazilian Journal of Pharmaceutical Sciences, May, 2010)

“This book argues that hormesis (biphasic dose-response patterns) is an underlying process at all levels of biological organization. … The book appears to be written for risk assessors and researchers interested in dose-response relationships and cellular signaling pathways. … Physically, the book is nicely laid out with high-quality illustrations that enhance the text. The concept of the hormetic dose-response curve is worth further study, and may well lead to advances in pharmacology and other biomedical applications.” (Jennifer Gervais, Doody’s Review Service, February, 2011)

Editors and Affiliations

  • Lab. Neurosciences, National Institute on Aging, Baltimore, U.S.A.

    Mark P. Mattson

  • Dept. Environmental Health Sciences, University of Massachusetts, Amherst, U.S.A.

    Edward J. Calabrese

About the editors

Mark P. Mattson, Ph.D. is Chief of the Laboratory of Neurosciences at the National Institute on Aging in Baltimore, where he leads a multi-faceted research team that applies cutting-edge technologies in research aimed at understanding molecular and cellular mechanisms of brain aging and the pathogenesis of neurodegenerative disorders. He is also a Professor in the Department of Neuroscience at Johns Hopkins University School of Medicine. He has published more than 450 original research articles and numerous review articles, and has edited 10 books in the areas of mechanisms of aging and neurodegenerative disorders. Dr. Mattson has trained more than 60 postdoctoral and predoctoral students who have contributed to his being the most highly cited neuroscientist in the world.

Edward J. Calabrese, Ph.D. is a Professor and Program Director of
Environmental Health Science, at the University of Massachusetts in Amherst.

His research focuses on environmental toxicology with an emphasis on biological factors including genetic and nutritional factors that enhance susceptibility to pollutant toxicity and the environmental implications of toxicological hormesis. Dr. Calabrese has researched extensively in the area of host factors affecting susceptibility to pollutants, and is the author of more than 300 papers in scholarly journals, as well as 24 books in the field of toxicology and environmental pollution. Dr. Calabrese has received numerous awards including, most recently, the prestigious Marie Curie Prize.

Bibliographic Information

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • ISBN: 978-1-60761-495-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 219.99
Price excludes VAT (USA)
Hardcover Book USD 249.99
Price excludes VAT (USA)