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Amyloid and Related Disorders

Surgical Pathology and Clinical Correlations

  • Maria M. Picken MD, PhD, FASN
  • Ahmet Dogan, M.D., Ph.D.
  • Guillermo A. Herrera, M.D.

Part of the Current Clinical Pathology book series (CCPATH)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Introduction/General

    1. Front Matter
      Pages 1-1
    2. Mario Nuvolone, Giovanni Palladini, Giampaolo Merlini
      Pages 9-29
    3. Amanda K. Ombrello, Ivona Aksentijevich
      Pages 31-51
    4. Merrill D. Benson
      Pages 53-67
    5. Paweena Susantitaphong, Laura M. Dember, Bertrand L. Jaber
      Pages 69-80
    6. John M. Lee, Maria M. Picken
      Pages 105-110
  3. Non-amyloid Protein Deposits

  4. Diagnosis

  5. Ancillary Studies of Amyloidosis

    1. Front Matter
      Pages 273-273
    2. David L. Murray, Jerry A. Katzmann
      Pages 275-282
    3. Sujata Ramamurthy, Lawreen H. Connors, Carl J. O’Hara
      Pages 283-290
    4. S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond, W. Edward Highsmith Jr.
      Pages 291-302
  6. Organ Involvement in Amyloidoses

    1. Front Matter
      Pages 303-303
    2. Carmela D. Tan, E Rene Rodriguez
      Pages 319-337
    3. Oscar W. Cummings, Merrill D. Benson
      Pages 339-360
    4. Adam J. Loavenbruck, Janean K. Engelstad, Christopher J. Klein
      Pages 361-374
  7. Clinical Issues and Therapy

    1. Front Matter
      Pages 375-375
    2. Merrill D. Benson
      Pages 393-397
    3. Amanda K. Ombrello
      Pages 399-403
    4. Timothy Craig Allen
      Pages 405-412
    5. Muriel Finkel
      Pages 413-417
  8. Back Matter
    Pages 419-425

About this book

Introduction

Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits.

Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included.   The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered.  This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.

Keywords

Abnormal protein deposition diseases Amyloidoses Cryoglobulinemia Plasma cell dyscrasia Renal pathology

Editors and affiliations

  • Maria M. Picken MD, PhD, FASN
    • 1
  • Ahmet Dogan, M.D., Ph.D.
    • 2
  • Guillermo A. Herrera, M.D.
    • 3
  1. 1.Bldg#110, Rm#2242, Department of PathologyLoyola University Medical CenterMaywoodUSA
  2. 2., Department of Laboratory Medicine and PaMayo ClinicRochesterUSA
  3. 3., Department of Renal PathologyBostwick LaboratoriesOrlandoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-389-3
  • Copyright Information Springer Science+Businees Media, LLC 2012
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-60761-388-6
  • Online ISBN 978-1-60761-389-3
  • Buy this book on publisher's site