Methods and Applications

  • Edgar Jacoby

Part of the Methods in Molecular Biology book series (MIMB, volume 575)

Table of contents

  1. Front Matter
    Pages i-x
  2. K. V. Balakin, Y. A. Ivanenkov, N. P. Savchuk
    Pages 21-46
  3. Jeremy M. Murray, Dirksen E. Bussiere
    Pages 47-92
  4. Ratna Singh, Andrea Mozzarelli
    Pages 93-122
  5. Garland R. Marshall, Daniel J. Kuster, Ye Che
    Pages 123-158
  6. Sarma A. R. P. Jagarlapudi, K. V. Radha Kishan
    Pages 159-172
  7. Edgar Jacoby, Andreas Boettcher, Lorenz M. Mayr, Nathan Brown, Jeremy L. Jenkins, Joerg Kallen et al.
    Pages 173-194
  8. Michael J. Keiser, Jérôme Hert
    Pages 195-205
  9. Josef Scheiber, Jeremy L. Jenkins
    Pages 207-223
  10. Richard J. Brennan, Tatiana Nikolskya, Svetlana Bureeva
    Pages 225-247
  11. Ruben Abagyan, Irina Kufareva
    Pages 249-279
  12. Ulrich Schopfer, Caroline Engeloch, Frank Höhn, Hervé Mees, Jennifer Leeds, Fraser Glickman et al.
    Pages 297-316
  13. Back Matter
    Pages 317-320

About this book


The establishment, analysis, prediction, and expansion of a comprehensive ligand-target Structure-Activity Relationship (SAR) in the post-genomic era presents a key research challenge for this century. In Chemogenomics: Methods and Applications, experts from academia and industry explore cutting-edge in vitro and in silico approaches available today and outline the relevant aspects of chemistry, biology, and molecular informatics which are the cornerstones of chemogenomics, thus combining introductory concepts with detailed methods and protocols. Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery. As a volume in the highly successful Methods in Molecular Biology™ series format, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and practical, Chemogenomics: Methods and Applications presents content which will be of enormous value to those striving for the discovery of new and better therapies for diseases.


Compound library design Drug discovery Knowledge-based approaches Ligand-target SAR Protein kinase inhibitors Secondary structure Small molecules Structure-Activity Relationship matrix molecular biology protein family

Editors and affiliations

  • Edgar Jacoby
    • 1
  1. 1.BaselSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-273-5
  • Online ISBN 978-1-60761-274-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site