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CNS Cancer

Models, Markers, Prognostic Factors, Targets, and Therapeutic Approaches

  • Erwin G. Meir

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xli
  2. Animal Models for Central Nervous Tumors

    1. Front Matter
      Pages 1-1
    2. Marcela Assanah, Kim A. Lopez, Jeffrey N. Bruce, Peter Canoll
      Pages 3-27
    3. Tod D. Holland, Eric C. Holland
      Pages 29-43
    4. C. Ryan Miller, Natalie O. Karpinich, Qian Zhang, Elizabeth Bullitt, Serguei Kozlov, Terry Van Dyke
      Pages 119-145
    5. Tomoko Ozawa, C. David James
      Pages 147-161
  3. Prognostic Factors and Biomarkers

    1. Front Matter
      Pages 281-281
    2. Shaoman Yin, Erwin G. Van Meir
      Pages 283-314
    3. David Stokoe, Frank B. Furnari
      Pages 315-357
    4. Rameen Beroukhim, Gaddy Getz, Ingo K Mellinghoff
      Pages 395-413
    5. Liliana Soroceanu, Charles S. Cobbs
      Pages 415-440
    6. YeoHyeon Hwang, Khatri Latha, Anupama Gururaj, Marta Rojas, Oliver Bogler
      Pages 441-459
    7. Bo Hu, Shi-Yuan Cheng
      Pages 461-506
    8. Erik P. Sulman, Marisol Guerrero, Ken Aldape
      Pages 529-551
    9. Rongcai Jiang, Jian Yi Li, Gregory N. Fuller, Wei Zhang
      Pages 553-575
    10. Raman P. Nagarajan, Joseph F. Costello
      Pages 615-650
    11. Clark C. Chen, Kristopher T. Kahle, Kimberly Ng, Masayuki Nitta, Alan D’Andrea
      Pages 679-711
    12. Jeremy N. Rich
      Pages 713-728
  4. Therapeutic Targets and Targeting Approaches

    1. Front Matter
      Pages 729-729
    2. Elizabeth R. Gerstner, Tracy T. Batchelor
      Pages 731-747
    3. Michael G. Ozawa, Fernanda I. Staquicini, Richard L. Sidman, Renata Pasqualini, Wadih Arap
      Pages 775-787
    4. Hyunsuk Shim
      Pages 813-845
    5. Waldemar Debinski, Jill Wykosky
      Pages 847-863
    6. Joanne E. Ayriss, Chien-Tsun Kuan, Susan T. Boulton, David A. Reardon, Darell D. Bigner
      Pages 865-898
    7. Saikh Jaharul Haque, Pankaj Sharma
      Pages 899-918
    8. Sameer Agnihotri, Diana Munoz, Abhijit Guha
      Pages 919-932
    9. Roger Abounader, John Laterra
      Pages 933-952
    10. Anita C. Bellail, Patrick Mulligan, Chunhai Hao
      Pages 977-1009
    11. Peter Pyrko, Axel H. Schönthal, Thomas C. Chen
      Pages 1037-1056
    12. Jennifer M. Atkinson, Richard J. Gilbertson, Jeremy N. Rich
      Pages 1057-1075

About this book

Introduction

CNS Cancer: Models, Markers, Prognostic Factors and Therapeutic Approaches

Erwin G. Van Meir

Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies.This makes it an especially opportune time to assemble some of the best investigators in the field to review the "state of the art" in the various arenas that comprise the assault on CNS tumors. While the lethality of these tumors has remained dismal over the past decades, there is finally real reason for optimism as our knowledge base grows exponentially larger.

The major areas of this endeavor are displayed in CNS Cancer: Models, Markers, Prognostic Factors and Therapeutic Approaches. Each of the chapters in the book represents illustrative examples of the road from discovery through translation to clinical importance, although many begin the journey at different parts of this continuum. This includes several chapters on incredibly clever mouse models for deciphering the genetic wiring underlying the development of CNS tumors and how that wiring might be targeted for therapeutic benefit. A great deal of attention has been paid in the book to the development of genetic prognostic factors and biomarkers that could be used for assessing individual responses to therapies and so could lead to truly personalized medicine. Other possible prognostic factors/biomarkers that arise from an understanding of CNS tumor pathophysiology are discussed in some detail and include tumor vascularization and hypoxia. Several of the new and rapidly developing methodologies that allow these rapid advances are detailed for the reader as well and include RNA expression profiling, proteomic analyses of both tumors and biological fluids as well as profiling small non-coding RNAs and DNA modification. Finally, several chapters explore aspects of therapeutic targeting employing small molecules and combinations thereof, various sorts of cells, viruses and immune modulation. In sum, these treatises represent the cutting edge of research that is driven to be of benefit to patients with these dreaded diseases.

Erwin G. Van Meir is Professor of Neurosurgery and Hematology & Medical Oncology in the School of Medicine at Emory University. A native of Belgium, he obtained Bachelor’s degrees in Biology and Education at the University of Fribourg, Switzerland. Dr Van Meir is an active member of the International Neuro-Oncology community and served on the Board of Directors of the Society for Neuro-Oncology from 2004-2008. Dr. Van Meir currently serves on the Editorial Board of Neuro-Oncology, Frontiers in Bioscience, and International Journal of Oncology and is a former Associate Editor of the International Journal of Cancer. He has served as a reviewer for over 30 international scientific journals and for grant proposals from public and private agencies.

Keywords

CNS Nervous System angiogenesis brain brain tumor brain tumors cancer cell hypoxia imaging oncogenes research resistance transplantation tumor

Editors and affiliations

  • Erwin G. Meir
    • 1
  1. 1.School of MedicineEmory UniversityAtlantaU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60327-553-8
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-60327-552-1
  • Online ISBN 978-1-60327-553-8
  • Buy this book on publisher's site