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Oxidative Stress and Free Radical Damage in Neurology

  • Book
  • © 2011

Overview

Editors:
  1. Natan Gadoth

    1. Medical School, Dept. Neurology, Tel Aviv University, Tel Aviv, Israel

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  2. Hans Hilmar Göbel

    1. Neurochirurgische Klinik, Abt. Neuropathologie, Universitätsklinikum Mainz, Mainz, Germany

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  • Cutting edge research provided by leading scientists in the field Timely research data presented in accessible language Clinicians as well as basic researchers in neuroscience will find this volume to be an outstanding resource
  • Includes supplementary material: sn.pub/extras

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Role of Free Radicals in the Nervous System

    • Joseph Friedman
    Pages 1-17

  3. Why Is the Nervous System Vulnerable to Oxidative Stress?

    • Joseph Friedman
    Pages 19-27

  4. Perinatal Hypoxic-Ischemic Neural Injury and Free Radical Injury: A Fine Balance

    • M. Perlman, Po-Yin Cheung
    Pages 29-46

  5. Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy

    • K. G. Todd, L. L. Jantzie, Po-Yin Cheung
    Pages 47-63

  6. Oxidative Stress in Multiple Sclerosis Pathology and Therapeutic Potential of Nrf2 Activation

    • Helga E. de Vries, Gerty Schreibelt, Jack van Horssen
    Pages 65-77

  7. Free Radicals in Central Nervous System Inflammation

    • D. Craig Hooper, Marzena J. Fabis, Anirban Roy
    Pages 79-98

  8. The Role of Reactive Oxygen Species in the Pathogenesis of Traumatic Brain Injury

    • Esther Shohami, Ron Kohen
    Pages 99-118

  9. Distinct Roles of Cyclooxygenase-1 and Cyclooxygenase-2 in Inflammatory and Excitotoxic Brain Injury

    • Saba A¨d, Sang-Ho Choi, Christopher D. Toscano, Francesca Bosetti
    Pages 119-136

  10. Stroke and Oxidative Stress

    • Arianna Vignini
    Pages 137-152

  11. Free Radicals in Epilepsy

    • Tali Siman-Tov, Natan Gadoth
    Pages 153-167

  12. Neurological Disorders Associated with Iron Misdistribution: The Therapeutic Potential of Siderophores

    • Or Kakhlon, Bill Breuer, Arnold Munnich, Z. Ioav Cabantchik
    Pages 169-190

  13. Oxidative Stress in Parkinson's Disease

    • Jacob Vaya, Yuval Aluf, John P. M. Finberg
    Pages 191-223

  14. Tetrahydrobiopterin Deficiency

    • Mary Kay Koenig, Ian J. Butler
    Pages 225-234

  15. Radicals Attack the Ear The Toll: A Loss of Hearing

    • Haim Sohmer, Cahtia Adelman
    Pages 235-252

  16. Reactive Oxygen Species in Mitochondrial Encephalomyopathy: Mechanisms and Effects

    • Sun Young Park, Ronald G. Haller
    Pages 253-292

  17. Potential Role of Oxidative Damage in Neurological Manifestations of Acute Intermittent Porphyria

    • Elena Pischik, Raili Kauppinen
    Pages 293-311

  18. Back Matter

    Pages 313-323
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About this book

The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.

Editors and Affiliations

  • Medical School, Dept. Neurology, Tel Aviv University, Tel Aviv, Israel

    Natan Gadoth

  • Neurochirurgische Klinik, Abt. Neuropathologie, Universitätsklinikum Mainz, Mainz, Germany

    Hans Hilmar Göbel

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