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Drug-DNA Interaction Protocols

  • Keith R. Fox

Part of the Methods in Molecular Biology book series (MIMB, volume 613)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Aurore Guédin, Laurent Lacroix, Jean-Louis Mergny
    Pages 25-35
  3. Richard T. Wheelhouse, Jonathan B. Chaires
    Pages 55-70
  4. Fitsumbirhan Araya, Graham G. Skellern, Roger D. Waigh
    Pages 71-88
  5. Kate Coldwell, Suzanne M. Cutts, Ted J. Ognibene, Paul T. Henderson, Don R. Phillips
    Pages 103-118
  6. Hao Wang, Charles A. Laughton
    Pages 119-131
  7. Derrick Watkins, Tinoush Moulaei, Seiji Komeda, Loren Dean Williams
    Pages 133-152
  8. Antonia S. Cardew, Keith R. Fox
    Pages 153-172
  9. Vidya Subramanian, Robert M. Williams, Dale L. Boger, Karolin Luger
    Pages 173-192
  10. Benny J. Evison, Don R. Phillips, Suzanne M. Cutts
    Pages 207-222
  11. Paul Peixoto, Christian Bailly, Marie-Hélène David-Cordonnier
    Pages 235-256
  12. Matthew R. Burrell, Nicolas P. Burton, Anthony Maxwell
    Pages 257-266
  13. Konstantinos Kiakos, Janet M. Hartley, John A. Hartley
    Pages 283-302
  14. Back Matter
    Pages 315-318

About this book

Introduction

The last few years have witnessed the creation of new generations of sequence reading compounds, which have incredible potential for targeting specific DNA sequences. In Drug-DNA Interaction Protocols, Second Edition, expert researchers explore these compounds, revealing how a deeper understanding of the structure of DNA, along with an improved ability to manipulate it, has led to much progress in recent years. Chapters describe a new arsenal of techniques for probing the interactions between drugs and DNA, including various biophysical techniques for quantifying these interactions and for describing them in molecular and atomic detail, and they comprehensively consider both molecular and cellular approaches. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.

 Authoritative and current, Drug-DNA Interaction Protocols, Second Edition, is a critical volume that includes a wide range of chapters, which together provide methods for assessing the strength and mode of binding, the sequence selectivity, and the effect on biological systems.

Keywords

Biophysical techniques Cellular approach DNA DNA-ligand interactions Promoter Sequence reading compounds Sequence selectivity Structural approach Telomere Termination transcription

Editors and affiliations

  • Keith R. Fox
    • 1
  1. 1.School of Biological SciencesUniversity of SouthamptonSouthamptonUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60327-418-0
  • Copyright Information Humana Press 2010
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60327-417-3
  • Online ISBN 978-1-60327-418-0
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site