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  • © 2010

The Dopamine Receptors

Editors:

  • Relies heavily on new knowledge

  • The use of knock-out mice and subtype-selective drugs merit discussion in stand-alone chapters

  • The field of G protein-coupled receptors has advanced significantly since the publication of the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors

  • Key aspects of this advanced model are specifically addressed in new chapters on dopamine receptor-interacting proteins and on dopamine receptor oligomerization

  • Includes supplementary material: sn.pub/extras

Part of the book series: The Receptors (REC)

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eBook USD 269.00
Price excludes VAT (USA)
  • ISBN: 978-1-60327-333-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 349.99
Price excludes VAT (USA)
Hardcover Book USD 349.99
Price excludes VAT (USA)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xii
  2. Structural Basis of Dopamine Receptor Activation

    • Irina S. Moreira, Lei Shi, Zachary Freyberg, Spencer S. Ericksen, Harel Weinstein, Jonathan A. Javitch
    Pages 47-73
  3. Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors

    • Olaf Prante, Miriam Dörfler, Peter Gmeiner
    Pages 101-135
  4. Dopamine Receptor Signaling: Intracellular Pathways to Behavior

    • Robert J. Romanelli, John T. Williams, Kim A. Neve
    Pages 137-173
  5. Regulation of Dopamine Receptor Trafficking and Responsiveness

    • Melissa L. Perreault, Vaneeta Verma, Brian F. O’Dowd, Susan R. George
    Pages 193-217
  6. Dopamine Receptor-Interacting Proteins

    • Lisa A. Hazelwood, R. Benjamin Free, David R. Sibley
    Pages 219-254
  7. Dopamine Receptor Oligomerization

    • Kjell Fuxe, Daniel Marcellino, Diego Guidolin, Amina Woods, Luigi Agnati
    Pages 255-280
  8. Dopamine Receptor Modulation of Glutamatergic Neurotransmission

    • Carlos Cepeda, Véronique M. André, Emily L. Jocoy, Michael S. Levine
    Pages 281-302
  9. Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice

    • Emanuele Tirotta, Claudia De Mei, Chisato Iitaka, Maria Ramos, Dawn Holmes, Emiliana Borrelli
    Pages 303-322
  10. Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models

    • Gerard J. O’Sullivan, Colm O’Tuathaigh, Katsunori Tomiyama, Noriaki Koshikawa, John L. Waddington
    Pages 323-371
  11. Dopamine Modulation of the Prefrontal Cortex and Cognitive Function

    • Jeremy K. Seamans, Trevor W. Robbins
    Pages 373-398
  12. In Vivo Imaging of Dopamine Receptors

    • Anissa Abi-Dargham, Marc Laruelle
    Pages 399-430
  13. Dopamine Receptors and the Treatment of Schizophrenia

    • Nathalie Ginovart, Shitij Kapur
    Pages 431-477
  14. Dopamine Receptors and the Treatment of Parkinson’s Disease

    • Eugenia V. Gurevich, Vsevolod V. Gurevich
    Pages 525-584
  15. Dopamine Receptor Genetics in Neuropsychiatric Disorders

    • Frankie H.F. Lee, Albert H.C. Wong
    Pages 585-632

About this book

Dopamine receptors are among the most validated drug targets for neuropsychiatric disorders such as schizophrenia and Parkinson’s disease, and are potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. The new knowledge brought from the creation and characterization of mice deficient in each of the subtypes and the development of increasingly subtype-selective agonists and antagonists has fueled many of the chapters new to this second edition, with the use of knock-out mice and subtype-selective drugs meriting discussion in stand-alone chapters. The field of G protein-coupled receptors has also advanced significantly since the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors. This second edition of Dopamine Receptors will be of interest to neurobiologists, pharmacologists and molecular biologists who study the brain, as well as neurologists working on psychiatric diseases.

Keywords

  • Parkinson
  • Psychopharmacology
  • attention deficit hyperactivity disorder (ADHD)
  • dopamine
  • neurons
  • physiology
  • receptors

Reviews

...extremely well-written and thoroughly referenced... All neuroscientists searching for an invaluable reference which provides a clearer understanding of the dopamine field and its future direction should have this book at their fingertips. -Journal of Medicinal Chemistry

Editors and Affiliations

  • Portland VA Medical Center (R & D-30), Portland, U.S.A.

    Kim A. Neve

Bibliographic Information

Buying options

eBook USD 269.00
Price excludes VAT (USA)
  • ISBN: 978-1-60327-333-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 349.99
Price excludes VAT (USA)
Hardcover Book USD 349.99
Price excludes VAT (USA)