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Bacterial Pathogenesis

Methods and Protocols

  • Frank R. DeLeo
  • Michael Otto

Part of the Methods in Molecular Biology™ book series (MIMB, volume 431)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Mechanisms of Bacterial Pathogenesis

    1. Front Matter
      Pages 1-1
    2. Michelle A. Chaussee, Emily J. McDowell, Michael S. Chaussee
      Pages 15-24
    3. Scott A. Rice, Diane McDougald, Michael Givskov, Staffan Kjelleberg
      Pages 55-68
    4. James M. Battisti, Sandra J. Raffel, Tom G. Schwan
      Pages 69-84
    5. Philip E. Stewart, Patricia A. Rosa
      Pages 85-95
  3. Host-Pathogen Interaction

  4. Animal Models of Bacterial Infection

    1. Front Matter
      Pages 223-223
    2. Jagath L. Kadurugamuwa, Kevin P. Francis
      Pages 225-239
    3. Paul Sumby, Anne H. Tart, James M. Musser
      Pages 255-267
  5. Identification of Therapeutic Targets and Typing Methods

    1. Front Matter
      Pages 269-269
    2. Lefa E. Alksne, Paul M. Dunman
      Pages 271-283
    3. Barun Mathema, Jose Mediavilla, Barry N. Kreiswirth
      Pages 285-305
  6. Back Matter
    Pages 307-311

About this book

Introduction

Bacterial infections affect world health today as a leading cause of morbidity and mortality. Pathogenic bacteria routinely command a broad spectrum of niches in the human host, making an understanding of pathogenesis mechanisms crucial to the development of prophylactics and treatment for bacterial diseases. A variety of in vitro methods, in vivo animal model systems and cutting-edge genomics assays have arisen in the effort to study bacterial pathogenesis and identify potential therapeutic targets. In Bacterial Pathogenesis, in-depth methods and state-of-the-art protocols are presented for investigating specific mechanisms of pathogenesis for a wide range of bacteria. This invaluable collection includes protocols to study host-pathogen interactions, animal models of infection, and novel approaches to identifying therapeutic targets designed to control infections. Up-to-date molecular typing methods for Staphylococcus aureus and a new model of streptococcal pharyngitis in non-human primates are also included. Bacterial Pathogenesis will prove an invaluable collection for microbiologists, immunologists, cell biologists and infectious disease clinicians - and indispensable to all science researchers interested in studying pathogenic bacteria and related disease processes.

Keywords

Microarray bacterial infection bacterial pathogenesis gene expression genes hybridization infections infectious disease world health

Editors and affiliations

  • Frank R. DeLeo
    • 1
  • Michael Otto
    • 2
  1. 1.Pathogen Host-Cell Biology Section, Laboratory of Human Bacterial PathogenesisRocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of HealthHamilton
  2. 2.Pathogen Molecular Genetics Section, Laboratory of Human Bacterial PathogenesisRocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of HealthHamilton

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60327-032-8
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-740-2
  • Online ISBN 978-1-60327-032-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site