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Checkpoint Responses in Cancer Therapy

  • Wei Dai

Part of the Cancer Drug Discovery and Development• book series (CDD&D)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Erik S. Knudsen, Wesley A. Braden
    Pages 1-17
  3. Christian Klein, Lyubomir T. Vassilev
    Pages 19-56
  4. Joseph M. Ackermann, Wafik S. El-Deiry
    Pages 93-116
  5. Takumi Kawabe
    Pages 117-133
  6. Timothy A. Yap, L. Rhoda Molife, Johann S. de Bono
    Pages 135-162
  7. Minoru Toyota, Lisa Kashima, Takashi Tokino
    Pages 163-176
  8. Miguel A. Villalona-Calero, Larry Schaaf, Robert Turowski
    Pages 177-205
  9. Vasiliki Sarli, Athanassios Giannis
    Pages 207-226
  10. Jungseog Kang, Hongtao Yu
    Pages 227-241
  11. Kishore Shakalya, Daruka Mahadevan
    Pages 243-269
  12. Wei Dai, Yali Yang, Ning Jiang
    Pages 271-290
  13. Back Matter
    Pages 311-314

About this book

Introduction

Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called "checkpoints" – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.

Keywords

DNA apoptosis biotechnology cancer cancer research cancer therapy cell cell cycle checkpoint chemotherapy development drug drug design drug development research

Editors and affiliations

  • Wei Dai
    • 1
  1. 1.Department of Environmental MedicineNew York University School of MedicineTuxedo

Bibliographic information